Major Depressive Disorder Clinical Trial
Official title:
Comparative Effectiveness Clinical Trial of Magnetic Seizure Therapy (MST) Compared to Electroconvulsive Therapy (MST) in Major Depressive Disorder
This study was a prospective, open-label comparative effectiveness clinical trial, comparing magnetic seizure therapy (MST) to ECT in patients with Major Depressive Disorder (MDD).
Magnetic seizure therapy (MST) has previously demonstrated fewer cognitive side effects than
ECT in randomized trials of efficacy. However, there are currently no real-world
effectiveness trials guided by the clinical decision making of the ECT psychiatrist as deemed
best for the patient. The aims of this study are to: (1) Evaluate the comparative
effectiveness of MST versus ECT in patients with MDD, and (2) Compare the cognitive adverse
effects of MST and ECT, (3) Explore changes in SPECT that is associated with MST treatment
and treatment response.
Patients will be clinically assigned to either ECT (n=30) or HD-MST (n=30) twice a week.
Efficacy will be primarily assessed by the Hamilton Depression Rating Scale-21 (HAMD-21);
primary cognitive side effects were assessed by Time to Reorientation (TRO) and secondarily
cognitive battery. Brain SPECT will be done for patients before and after MST.
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