Major Depressive Disorder Clinical Trial
Official title:
Pilot Clinical Trial for the Evaluation of Feedback Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder
Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on patients with Major Depressive Disorder (MDD).
Central Hypothesis: Non-invasive brain stimulation that suppresses alpha oscillation reduces
cortical hyperactivity and causes a clinical improvement
Aim 1: To conduct a pilot clinical trial to establish feasibility and to collect first
effectiveness data for the use of tACS to renormalize pathological alpha oscillations in the
dorsolateral prefrontal cortex (dl-pfc) of unmedicated patients with MDD by comparing MADRS
scores from baseline and one month follow up.
Aim 2: Compare alpha oscillation power from resting state EEG recordings on the first and
last day of stimulation. Collect EEG data at the one month follow up visit using this data to
analyze alpha frequency activity as a pilot study for derivation of EEG biomarkers.
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