Major Depressive Disorder Clinical Trial
Official title:
Clinical Effects of Electroconvulsive Therapy in Severe Depression and Concomitant Changes in Cerebral Glucose Metabolism - an Exploratory Study
There exist already a few studies that have measured changes of brain metabolism pre and
post Electroconvulsive Therapy (ECT) by Positron emission tomography (PET) but these were
all performed in a small number of patients and used different methodologies. It is
therefore not surprising that these investigations provided inconsistent results, as
reviewed previously {{23 Schmidt,E.Z. 2008}}.
In patients with treatment-refractory major depressive episodes, the investigators here
therefore probed (a) whether changes in cerebral glucose metabolism measured by PET occur
after treatment with ECT and (b) whether these correlate with the clinical amelioration of
symptoms. To pursue this goal, the investigators assessed clinical effects, neurocognitive
function, and brain metabolism using 18F-Fluoro-deoxyglucose (18F-FDG) PET at baseline and
at the end of treatment.
Patients with a treatment refractory depression - defined as absent clinical improvement of
depressive symptoms after at least two trials with antidepressants from different
pharmacologic classes adequate in dose, duration of at least 6 weeks, and compliance {{30
Berlim,M.T. 2007}} - in whom ECT had been intended on clinical grounds were consecutively
asked for participation in this study. Patients had to be between 18 and 80 years old and to
be physically healthy.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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