Major Depressive Disorder Clinical Trial
Official title:
A Double-blind, Randomised, Multicenter, Comparative Study of Escitalopram and Duloxetine in Outpatients With Major Depressive Disorder
The primary objective of this study was to compare the efficacy of escitalopram with that of duloxetine in outpatients with Major Depressive Disorder (MDD) after 24 weeks of treatment. The study hypothesis was that there were clinically important differences between the two drugs in terms of efficacy and adverse event profiles.
Depression is a common mental disorder that presents with depressed mood, loss of interest
or pleasure, disturbed sleep or appetite, low energy, feelings of guilt or low self-worth,
and poor concentration. The lifetime prevalence of Major Depressive Disorder (MDD) in
community samples is 10-25% for women and 5-12% for men. Depression may become chronic or
recurrent and lead to substantial impairments in an individual's ability to take care of his
or her everyday responsibilities. At its worst, depression may lead to suicide. Depression
is recurrent in 75-80% of patients and becomes chronic in 15-20% of depressed patients.
The selective serotonin reuptake inhibitors (SSRIs) have become the leading class of
antidepressants throughout the world. The efficacy and safety of SSRIs in the treatment of
depression has been demonstrated in several clinical trials. With respect to safety, the
studies show an advantage for the SSRIs over the older antidepressants. If the prescribing
physicians are to make a well-founded judgement in their choice of drug factors like
efficacy, safety, quality of life, and health economics must be taken into consideration.
The primary aim of this study is to compare the efficacy of escitalopram with that of the
serotonin norepinephrine reuptake inhibitors (SNRIs) duloxetine in the treatment of MDD.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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