Major Depressive Disorder Clinical Trial
Official title:
A Controlled Study of Ultrabrief Pulsewidth ECT (Electroconvulsive Therapy)
Electroconvulsive Therapy (ECT) remains essential to contemporary psychiatric practice and
is one of the safest and most effective treatments available for depression. Despite modern
advances in pharmacotherapy, about 15-20 per cent of all hospitalised patients receive
treatment with ECT. Its use, however, is limited by concerns over associated cognitive side
effects.
Recent research has suggested that using an ultrabrief pulsewidth with ECT may greatly
reduce cognitive side effects, while maintaining efficacy (Sackeim et al 2008). Preliminary
results were positive for unilateral ECT, however, suggest that for bilateral ECT, dosing
may need to be adjusted to preserve efficacy while reducing side effects. This study will
examine the relative cognitive side effects and efficacy of right unilateral and bilateral
ECT given with a standard pulsewidth or an ultrabrief pulsewidth. Some participants will
also receive an MRI scan before and after ECT.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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