Major Depressive Disorder Clinical Trial
Official title:
Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder
The purpose of this study is to assess the effect of escitalopram on sleep architecture
utilizing a prospective design.
Hypothesis: Escitalopram will improve REM latency in patients with MDD that have responded
clinically to treatment.
Disturbance of sleep is a prominent symptom in depressive disorders. Alterations of sleep
patterns in depressed patients include insomnia, frequent awakenings, early wake-up and
non-refreshing sleep. Polysomnographic recordings have confirmed these reports, reporting
reduced latency of the first REM episode of the night, with decreased density of rapid eye
movements, and enhancement of total percentage of REM sleep, a reduction of deep slow wave
sleep (SWS) and increase in night awakenings (Benca et al., Classification of sleep
disorders).
The effects of antidepressant drugs on depression and sleep disorders, specifically SSRIs,
have been thoroughly researched. The effects of escitalopram on sleep in depressed patients
have been reported using a retrospective design, and in this proposed protocol, we suggest
to assess the effect of escitalopram on sleep architecture utilizing a prospective design.
Hypothesis:
Escitalopram will improve REM latency in patients with MDD that have responded clinically to
treatment.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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