Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT04970017 |
| Other study ID # |
17200538 |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2021 |
| Est. completion date |
January 2022 |
Study information
| Verified date |
February 2021 |
| Source |
Assiut University |
| Contact |
Mohamed Abdellatif, MSC |
| Phone |
+201001073747 |
| Email |
mohamed.abdellatief[@]med.au.edu.eg |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
To verify whether GLS and LV mechanical dispersion, measured by two-dimensional
speckle-tracking echocardiography (2D-STE) correlate with LV scar burden measured by cardiac
MRI in patients with ischemic heart disease.
Description:
Evaluation of presence, localization, and extent of left ventricular(LV) scar tissue in
patients with ischaemic heart disease (IHD) is of fundamental importance in clinical
practice. It affects the decision making regarding revascularization and is a determinant of
subsequent mortality. (Mele, Fiorencis et al. 2016) Late gadolinium contrast-enhanced cardiac
magnetic resonance (LGE-CMR) is considered the current gold standard technique for assessment
of the scar burden in IHD patients. However, it is not readily accessible in many areas due
to availability and cost issues.(Abou, Prihadi et al. 2020), (Bendary, Afifi et al. 2019)
Several recent studies suggested 2-D speckle tracking strain as a potential surrogate for
cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) imaging. This would
be useful in cases where CMR is not available, gadolinium contrast is contraindicated, or in
patients at greater risk of adverse long term events. (Erley, Genovese et al. 2019) Among
echocardiography derived strain measurements, global longitudinal strain (GLS) was shown to
be superior to global circumferential strain (GCS) in its ability to detect subtle myocardial
abnormalities due to better reproducibility (Erley et al, 2019). Left ventricular mechanical
dispersion (LVMD) is also considered a valuable parameter that was associated with outcomes
after myocardial infarction. (Abou, Prihadi et al. 2020).
Despite the growing number of strain related studies in the literature, it is not clear
whether the relationship of strain measurements with LGE is strong enough for strain to be
considered as a surrogate. (Erley, Genovese et al. 2019). Also, the differences between GLS
and LV MD among strain components in this context are not well established.
