Ischemic Heart Disease Clinical Trial
Official title:
The Catholic Imaging and Functional Research Cohort (C-iFR)
1. The primary technical endpoint was the diagnostic performance of the QFR against the
FFR.
2. The primary clinical endpoint was target vessel failure (TVF) between two groups
distributed by a QFR cut-off value of 0.8
The quantitative flow ratio (QFR) is a novel angiography-based tool used to assess functional
ischemia caused by coronary stenosis. Computation of the fractional flow reserve (FFR) from
coronary angiography is based on 3D reconstruction and fluid dynamics algorithms using a
modified frame count; therefore, we do not need to induce hyperemia or perform invasive
procedures with a pressure wire to measure it. During the past few years, the diagnostic
accuracy of the QFR was investigated and showed favorable outcomes. However, data for
patients with acute coronary syndrome are lacking. In addition, no data are available for the
performance of the QFR in predicting clinical outcomes. We aim to evaluate the diagnostic
performance of the QFR versus the FFR and their predictive abilities for clinical outcome in
a real-world all-comer population.
The Catholic imaging and Functional Research (C-iFR) Cohort was designed to evaluate the
diagnostic performance and clinical outcome predictive ability of the QFR in consecutive
patients undergoing CAG and the FFR at 4 major cardiac centers in Korea from January 2012 to
May 2018. All hospitals (Seoul St. Mary's Hospital, Seoul; St. Paul's Hospital, Seoul;
Incheon St. Mary's Hospital, Incheon; Uijeongbu St. Mary's Hospital, Uijeongbu) perform a
high volume of percutaneous coronary intervention (PCI) procedures, with more than 800 PCI
procedures performed per year. This QFR registry includes demographic characteristics,
clinical information, laboratory data, QFR findings, and FFR findings, with clinical outcome
data collected over 4 years (a median of 2 years)
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Recruiting |
NCT06002932 -
Comparison of PROVISIONal 1-stent Strategy With DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
|
N/A | |
| Active, not recruiting |
NCT04562805 -
Infinity-Swedeheart Registry Based Randomized Clinical Trial (R-RCT)
|
N/A | |
| Recruiting |
NCT05292079 -
CAPTURER PMCF Study ( rEPIC04D )
|
||
| Recruiting |
NCT05292014 -
ANGIOLITE PMCF Study ( rEPIC04F )
|
||
| Recruiting |
NCT05292118 -
Navitian PMCF Study ( rEPIC04C )
|
||
| Recruiting |
NCT05292092 -
Essential Pro PMCF Study ( rEPIC04E )
|
||
| Completed |
NCT05292105 -
NC Xperience PMCF Study( rEPIC04B)
|
||
| Completed |
NCT03076801 -
Does Choral Singing Help imprOve Stress in Patients With Ischemic HeaRt Disease?
|
N/A | |
| Not yet recruiting |
NCT04153383 -
Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery
|
||
| Recruiting |
NCT02982434 -
The New Pharmaceutical Composition Containing Botulinum Toxin to Treat Atrial Fibrillation
|
Phase 2 | |
| Recruiting |
NCT02729064 -
Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose
|
Phase 1 | |
| Completed |
NCT02468401 -
Prevention of Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions
|
N/A | |
| Completed |
NCT02759406 -
Evaluation of the Palmaz Mach-5 Grooved Bare Metal Coronary Stent System Versus the Palmaz Bare Metal Coronary Stent System in Patients With Symptomatic Ischemic Heart Disease: A Safety and Performance Study
|
N/A | |
| Recruiting |
NCT01681381 -
Evaluate Safety And Effectiveness Of The Tivoli® DES and The Firebird2® DES For Treatment Coronary Revascularization
|
N/A | |
| Completed |
NCT01699802 -
Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)
|
N/A | |
| Completed |
NCT01604213 -
Effects of Vildagliptin/Metformin Combination on Markers of Atherosclerosis, Thrombosis, and Inflammation in Diabetics With Coronary Artery Disease
|
Phase 4 | |
| Completed |
NCT01724567 -
Copenhagen Study of Obese Patients With Ischemic Heart Disease Undergoing Low Energy Diet or Interval Training
|
N/A | |
| Completed |
NCT01334268 -
RESOLUTE China RCT
|
N/A | |
| Completed |
NCT02159235 -
Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD)
|
N/A |