Ischemic Heart Disease Clinical Trial
Official title:
The Catholic Imaging and Functional Research Cohort (C-iFR)
1. The primary technical endpoint was the diagnostic performance of the QFR against the
FFR.
2. The primary clinical endpoint was target vessel failure (TVF) between two groups
distributed by a QFR cut-off value of 0.8
The quantitative flow ratio (QFR) is a novel angiography-based tool used to assess functional
ischemia caused by coronary stenosis. Computation of the fractional flow reserve (FFR) from
coronary angiography is based on 3D reconstruction and fluid dynamics algorithms using a
modified frame count; therefore, we do not need to induce hyperemia or perform invasive
procedures with a pressure wire to measure it. During the past few years, the diagnostic
accuracy of the QFR was investigated and showed favorable outcomes. However, data for
patients with acute coronary syndrome are lacking. In addition, no data are available for the
performance of the QFR in predicting clinical outcomes. We aim to evaluate the diagnostic
performance of the QFR versus the FFR and their predictive abilities for clinical outcome in
a real-world all-comer population.
The Catholic imaging and Functional Research (C-iFR) Cohort was designed to evaluate the
diagnostic performance and clinical outcome predictive ability of the QFR in consecutive
patients undergoing CAG and the FFR at 4 major cardiac centers in Korea from January 2012 to
May 2018. All hospitals (Seoul St. Mary's Hospital, Seoul; St. Paul's Hospital, Seoul;
Incheon St. Mary's Hospital, Incheon; Uijeongbu St. Mary's Hospital, Uijeongbu) perform a
high volume of percutaneous coronary intervention (PCI) procedures, with more than 800 PCI
procedures performed per year. This QFR registry includes demographic characteristics,
clinical information, laboratory data, QFR findings, and FFR findings, with clinical outcome
data collected over 4 years (a median of 2 years)
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