Ischemic Heart Disease Clinical Trial
Official title:
Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery
The purpose of this study is to determine Isoflurane's dose-dependent effect on left ventricular (LV) systolic function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular systolic velocity at three different isoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE) in cardiac surgery patients.
Isoflurane is widely used in cardiac surgery patients due to its beneficial effects, but
many studies have shown that isoflurane reduces myocardial contractility in a dose-dependent
manner, and compromises left ventricular (LV) function.
Tissue Doppler imaging (TDI) of mitral annular velocity during the cardiac cycle has been
introduced as a reliable method for analysis of systolic and diastolic LV long-axis
function. Efficacy of systolic and diastolic TDI profiles, including systole (S'), early
early relaxation (E')and atrial contraction (A') have been suggested to be useful in
predicting the impact of isoflurane on LV systolic and diastolic function.
The investigators hypothesized that isoflurane, even at a clinical dosage, would affects
intraoperative LV systolic function in a dose-dependent manner and thus produce significant
changes int the TDI profiles of systolic mitral annular velocity (S').
So the investigators planned to study the changes in S' of lateral mitral annulus at the
clinical isoflurane dosage during remifentanil based anesthesia for cardiac surgery.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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