Clinical Trials Logo
  1. Home
  2. Ischemic Heart Disease
  3. NCT03786965
  4. Details
NCT03786965 Clinical Trial

Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.

Ischemic Heart Disease Clinical Trial

— MPO-CSP  

Official title:
Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03786965
Other study ID # ?22/18-H
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date December 20, 2018
Est. completion date December 20, 2025

Study information
Verified date November 2021
Source St. Petersburg State Pavlov Medical University
Contact Alexander Nemkov, PhD
Phone +7-921-795-00-47
Email nemk_as@mail.ru
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.

Description:

To assess outcomes after cardiac surgery procedures. To investigate serum level of myeloperoxidase, morphology of left atrium appendage, to perform genetic analysis and cell biology.

Recruitment information / eligibility
Status Recruiting
Enrollment 2000
Est. completion date December 20, 2025
Est. primary completion date July 20, 2025
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - ischemic heart disease with indications for operation - valve disease with indications for operation - ischemic heart disease combined with valve disease with indications for operation Exclusion Criteria: - patient refusal

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• On-pump CABG
On-pump CABG
• Off-pump CABG
Off-pump CABG
• Pump-assisted CABG
Pump-assisted CABG
• Valve Repair Procedure without CABG.
Valve Repair Procedure without CABG (open heart procedure).
• Valve Repair Procedure with CABG.
Valve Repair Procedure with CABG (open heart procedure).

Locations
Country Name City State
Russian Federation Nikolai Bunenkov Saint-Petersburg Non-US/Non-Canadian

Sponsors (1)
Lead Sponsor Collaborator
St. Petersburg State Pavlov Medical University

Country where clinical trial is conducted

Russian Federation, 

Outcome
Type Measure Description Time frame Safety issue
Primary Death within 30 days after procedure. Death within 30 days after surgical procedure. within 30 days after procedure.
Primary Acute myocardial infarction. Acute myocardial infarction (ST-changes with troponin I > 10 ng/ml). within 30 days after procedure.
Primary Stroke. Stroke (MRI changes or corresponding neurologist record). within 30 days after procedure.
Primary Arrhythmia Any type of arrhythmia including AV-block. within 30 days after procedure.
Primary Renal dysfunction. Renal dysfunction if serum creatinine greater than 25% of upper reference range. within 30 days after procedure.
Primary Infection or febrile. Infection or febrile (t> 37 or CRP elevation or long regeneration of surgical wound). within 30 days after procedure.
Primary Respiratory dysfunction. Respiratory dysfunction (pulmonary ventilation longer than 2 days). within 30 days after procedure.
See also
  Status Clinical Trial Phase
Recruiting NCT05654272 - Development of CIRC Technologies
Recruiting NCT06002932 - Comparison of PROVISIONal 1-stent Strategy With DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions. N/A
Active, not recruiting NCT04562805 - Infinity-Swedeheart Registry Based Randomized Clinical Trial (R-RCT) N/A
Recruiting NCT05292079 - CAPTURER PMCF Study ( rEPIC04D )
Recruiting NCT05292118 - Navitian PMCF Study ( rEPIC04C )
Recruiting NCT05292092 - Essential Pro PMCF Study ( rEPIC04E )
Recruiting NCT05292014 - ANGIOLITE PMCF Study ( rEPIC04F )
Completed NCT05292105 - NC Xperience PMCF Study( rEPIC04B)
Completed NCT03076801 - Does Choral Singing Help imprOve Stress in Patients With Ischemic HeaRt Disease? N/A
Not yet recruiting NCT04153383 - Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery
Recruiting NCT02729064 - Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose Phase 1
Recruiting NCT02982434 - The New Pharmaceutical Composition Containing Botulinum Toxin to Treat Atrial Fibrillation Phase 2
Completed NCT02468401 - Prevention of Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions N/A
Completed NCT02759406 - Evaluation of the Palmaz Mach-5 Grooved Bare Metal Coronary Stent System Versus the Palmaz Bare Metal Coronary Stent System in Patients With Symptomatic Ischemic Heart Disease: A Safety and Performance Study N/A
Recruiting NCT01681381 - Evaluate Safety And Effectiveness Of The Tivoli® DES and The Firebird2® DES For Treatment Coronary Revascularization N/A
Completed NCT01604213 - Effects of Vildagliptin/Metformin Combination on Markers of Atherosclerosis, Thrombosis, and Inflammation in Diabetics With Coronary Artery Disease Phase 4
Completed NCT01699802 - Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa) N/A
Completed NCT01334268 - RESOLUTE China RCT N/A
Completed NCT01724567 - Copenhagen Study of Obese Patients With Ischemic Heart Disease Undergoing Low Energy Diet or Interval Training N/A
Completed NCT02159235 - Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD) N/A