Hypertension Clinical Trial
To determine the impact of the treatment of hypertension on the epidemiological analyses of blood pressure from observational studies.
BACKGROUND:
With the use of antihypertensive medication increasing steadily over the last 25 years,
treatment for hypertension is now common. Given the high prevalence of treatment for
hypertension, researchers can no longer assume that participants in epidemiologic studies
represent natural blood pressure measures, as opposed to treated blood pressure measures.
The effect of this high prevalence of treatment, however, has not been fully investigated.
Although it might seem that studies of "natural history" are no longer relevant, great
interest currently exists in establishing both environmental and genetic determinants of
blood pressure. Additionally, there currently is a renewed interest in refining treatment
guidelines. For example, the need to account for absolute as well as relative risk has been
hotly debated in recent years. The need will continue to exist, therefore, to analyze
observational data sets to meet the evolving interest in the determinants of blood pressure
and to meet the requirements for more refined risk estimates.
DESIGN NARRATIVE:
To investigate the effect of blood pressure treatment on the analysis of epidemiologic
studies, the investigators conducted two interrelated analyses using simulation studies and
data from five observational studies: The Framingham Heart Study; the NHANES I, II, and III
cohorts; and The International Collaborative Study of Hypertension in Blacks (ICSHIB). They
first conducted simulation studies to examine the behavior of different methodologies in
each of two common analytic settings: relating body mass index to level of systolic blood
pressure and relating level of systolic blood pressure to coronary heart disease mortality.
They planned to use the data from the five studies to derive the parameters for use in the
simulation studies. In these studies they quantified the level of bias that results from
ignoring the presence of blood pressure treatment in observational data. After conducting
their simulations studies, they repeated the analysis of the relationship between body mass
index and systolic blood pressure using available empirical data.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
;
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
| Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
| Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
| Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
| Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
| Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
| Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
| Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
| Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
| Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
| Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
| Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
| Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |