Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT00005458 |
| Other study ID # |
4902 |
| Secondary ID |
R01HL041796 |
| Status |
Completed |
| Phase |
N/A
|
| First received |
May 25, 2000 |
| Last updated |
May 12, 2016 |
| Start date |
January 1991 |
| Est. completion date |
December 1991 |
Study information
| Verified date |
May 2000 |
| Source |
National Heart, Lung, and Blood Institute (NHLBI) |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
United States: Federal Government |
| Study type |
Observational
|
Clinical Trial Summary
To re-examine the relationship between suppressed anger, elevated blood pressure and
all-cause as well as coronary heart disease (CHD) mortality using data from the Life Change
Event Study (LCES) conducted on a representative sample of the Tecumseh Community Health
Study (TCHS), n=696, men and women, aged 30-69 in 1971-1972.
Description:
DESIGN NARRATIVE:
The psychosocial data (e.g. anger-expression, stressful life events) and some medical data
(e.g. blood pressure, smoking) were collected in 1971/72, while additional information about
other medical risk factors was collected in 1968/69. Mortality ascertainment and cause of
death was completed by the end of 1989, through TCHS staff, using the National Death Index
(NDI). The estimated cumulative 18-year mortality rate as of 1989 for the Tecumseh cohort of
the same age as the LCES sample was 26 percent for males and 16 percent for females.
Approximately 144 deaths were expected. Out of the total TCHS cohort deaths, 35 percent were
estimated to be due to CHD. Research questions tested included: (1) did suppressed anger
predict coronary heart disease mortality as well as all-cause mortality; (2) was the
relationship between suppressed anger and mortality modified by other risk factors (e.g.
blood pressure, marital stress, gender); (3) were there certain anger-coping strategies
among married couples which increased mortality risk for one or both members of the marital
pair.
Analyses were done at three levels: for the whole sample, separately for males and females,
and for a subgroup of 192 married couples it was done by 'pairs'. To determine univariate
association between anger-coping types and all-cause mortality, the percent deceased was
compared among persons grouped according to their anger responses. For the
situation-specific and total suppressed anger indices, the distribution of scores was
divided into thirds. The significance of each association was tested using chi-square
statistics. Logistic regression was employed to test for the significance of the association
between anger-coping measures and mortality controlling for sex, age, education, marital
stress, relative weight, smoking, systolic blood pressure, CHD status, bronchitis, and FEV1
scores. Logistic regression was also used to determine whether any of the risk factors,
particularly blood pressure, gender and marital stress, significantly modified the
relationship between suppressed anger and mortality. The design and measures of this study
had the potential to further identify specific person-situation characteristics associated
with higher risks of total as well as cause specific mortality which then could be used to
make more knowledgeable recommendations for health behavior interventions.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
