Heart Failure Clinical Trial
Official title:
Observational Study on Prevalence and Prognostic Value of Growth Hormone Deficiency in Patients With Chronic Heart Failure
Aim of this study is to define the possible detrimental effect of a lack of growth hormone, on the well-being and life expectation of patients affected by heart failure.
Growth hormone and its main effector IGF-1 have well-documented roles in the regulation of
cardiac and circulatory function. Evidence suggests that GH/IGF-1 exert a beneficial effect
on cardiac load, cardiac growth and remodeling, despite their hypertrophying action. Several
studies in the last years have demonstrated worse cardiovascular outcomes in adult patients
with GH deficiency and/or low levels of IGF-1.
A wide range of alterations in the GH/IGF-1 axis have been described to date in patients
with chronic heart failure (CHF): reductions in GH levels, reductions in IGF-1 and a pattern
of peripheral resistance to GH, in particular in patients with severe heart failure and
cardiac cachexia. Our study hypothesis is that an actual status of GH deficiency coexists
with CHF in a large percent of patients, and that it may represent a predictor of worse
functional status and possibly of a worse prognosis. Aim of this study is to explore the
latter hypothesis, comparing the clinical and functional evolution of patients with CHF and
GHD with that of a general CHF population.
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Observational Model: Cohort, Time Perspective: Prospective
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