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Heart Diseases clinical trials

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NCT ID: NCT00000614 Completed - Clinical trials for Cardiovascular Diseases

Prevention of Recurrent Venous Thromboembolism (PREVENT)

Start date: September 1998
Phase: Phase 3
Study type: Interventional

A multicenter randomized, double blind placebo controlled trial to determine the efficacy of long-term, low dose warfarin in the secondary prevention of venous thromboembolism.

NCT ID: NCT00000613 Completed - Depression Clinical Trials

CVD Risk and Health in Postmenopausal Phytoestrogen Users

Start date: April 1997
Phase: Phase 2
Study type: Interventional

To determine the acceptability and benefits of use of a dietary supplement of the phytoestrogen, genistein, versus placebo on heart disease risk factors, bone density, and psychosocial outcomes in postmenopausal women.

NCT ID: NCT00000612 Completed - Clinical trials for Cardiovascular Diseases

Soy Estrogen Alternative Study (SEA)

Start date: January 1996
Phase: Phase 2
Study type: Interventional

To conduct a three-armed trial assessing the effect of soy phytoestrogens on menopausal complaints, plasma lipids and lipoproteins, vaginal bleeding and endometrial proliferation, and health related quality of life.

NCT ID: NCT00000611 Completed - Clinical trials for Cardiovascular Diseases

Women's Health Initiative (WHI)

Start date: n/a
Phase: Phase 3
Study type: Interventional

To address cardiovascular disease, cancer, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women. The three major components of the WHI are: a randomized controlled clinical trial of hormone replacement therapy (HRT), dietary modification (DM), and calcium/vitamin D supplementation (CaD); an observational study (OS); and a community prevention study (CPS). On October 1, 1997, administration of the WHI was transferred to the NHLBI where it is conducted as a consortium effort led by the NHLBI in cooperation with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), and the National Institute on Aging (NIA).

NCT ID: NCT00000610 Completed - Clinical trials for Cardiovascular Diseases

Magnesium in Coronaries (MAGIC)

Start date: April 1998
Phase: Phase 3
Study type: Interventional

To determine whether early intravenous magnesium treatment of patients with suspected acute myocardial infarction reduces mortality.

NCT ID: NCT00000609 Completed - Heart Failure Clinical Trials

Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)

Start date: May 1997
Phase: Phase 3
Study type: Interventional

To compare conventional treatment of congestive heart failure (CHF) with two experimental interventions: amiodarone and an implantable cardioverter-defibrillator (ICD).

NCT ID: NCT00000608 Completed - Hypertension Clinical Trials

Dietary Patterns, Sodium Intake and Blood Pressure (DASH - Sodium)

Start date: February 1997
Phase: Phase 2
Study type: Interventional

To compare the effects of three levels of dietary sodium and two patterns of diet (a control diet and an intervention diet high in fruits, vegetables, and low fat dairy products and low in fat) on blood pressure in individuals with higher than optimal blood pressure or with Stage 1 hypertension.. DASH - Sodium built on and extended the results of the NHLBI-initiated Dietary Approaches to Stop Hypertension (DASH) study.

NCT ID: NCT00000607 Completed - Heart Failure Clinical Trials

Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH)

Start date: October 1997
Phase: Phase 3
Study type: Interventional

To conduct a randomized, unblinded clinical trial comparing the left ventricular assist device (LVAD) with maximum medical management in patients with end-stage heart failure who were not candidates for heart transplantation.

NCT ID: NCT00000605 Completed - Clinical trials for Cardiovascular Diseases

Estrogen and Graft Atherosclerosis Research Trial (EAGER)

Start date: August 1996
Phase: Phase 3
Study type: Interventional

To determine if postmenopausal hormone replacement therapy in women following coronary bypass surgery would reduce the occurrence of graft occlusion and delay the development of graft atherosclerosis.

NCT ID: NCT00000604 Completed - Clinical trials for Cardiovascular Diseases

Influence of CPB Temperature on CABG Morbidity

Start date: January 1994
Phase: Phase 2
Study type: Interventional

To compare three accepted modes of myocardial preservation, warm, tepid, and cold blood cardioplegia, coinciding with normothermic (37 degrees centigrade), tepid (32 degrees centigrade) and hypothermic (8 to 10 degrees centigrade) cardiopulmonary bypass (CPB) to define differences in neurologic function in coronary artery bypass graft (CABG) patients.