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Clinical Trial Summary

The purpose of this study is to better understand mental illness and will test the hypotheses that while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after lorazepam. This study will enroll participants between the ages of 16 and 60, who have a psychotic illness (such as psychosis which includes conditions like schizophrenia, schizoaffective disorder, and mood disorders). The study will also enroll eligible participants without any psychiatric illness, to compare their brains. The study will require participants to have 3-4 sessions over a few weeks. The initial assessments (may be over two visits) will include a diagnostic interview and several questionnaires (qols) to assess eligibility. Subsequently, there will will be two separate functional magnetic resonance imaging (fMRI) sessions in which lorazepam or placebo will be given prior to the MRI. During the fMRI the participants will also be asked to answer questions. Additionally, the participants will have their blood drawn, women of child bearing potential will have a urine pregnancy test, vital signs taken, and asked to complete more qols.


Clinical Trial Description

- Please note the collaborator (NIMH) is requesting that an NCT number be obtained prior to receiving the award number. - Initial assessment(s) may be done via videoconference due to Covid. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04004416
Study type Interventional
Source University of Michigan
Contact Clara Steeby, BS
Phone 734-615-3645
Email GABAStudy@med.umich.edu
Status Recruiting
Phase Phase 4
Start date January 16, 2020
Completion date February 28, 2025

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