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NCT05786521 Clinical Trial

Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults

Diabetes Mellitus, Type 2 Clinical Trial

Official title:
The Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Biomarkers of Aging in Older Overweight/Obese Adults With Insulin Resistance

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT05786521
Other study ID # 20220256HU
Secondary ID 5P30AG044271-08
Status Active, not recruiting
Phase Phase 4
First received
Last updated
Start date April 1, 2023
Est. completion date June 2025

Study information
Verified date May 2024
Source The University of Texas Health Science Center at San Antonio
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Semaglutide is a medication approved by the US Food and Drug Administration (FDA) as an antihyperglycemic (a drug that reduces glucoses in those with diabetes) and for weight management. This new study will help find out what effects, semaglutide has on people who take the drug and the drug's effect on physical function, body composition, and aging.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 20
Est. completion date June 2025
Est. primary completion date April 30, 2024
Accepts healthy volunteers No
Gender All
Age group 65 Years to 90 Years
Eligibility Inclusion Criteria: - Older than 65 - Have prediabetes or diabetes - BMI = 27.0 kg/m2 - Living independently (not in assisted living or nursing home) Exclusion Criteria: - Have heart disease - Have liver disease - Smoke

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Semaglutide Injectable Product
Semaglutide will be started at 0.25mg once a week for 4 weeks followed by 0.5mg once weekly for 4 weeks followed by 1.0mg once a week for 12 weeks.
Behavioral:
• Lifestyle Counseling
Lifestyle Counseling will be provided throughout study intervention

Locations
Country Name City State
United States UT Health San Antonio San Antonio Texas

Sponsors (2)
Lead Sponsor Collaborator
The University of Texas Health Science Center at San Antonio National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Lean body mass change Determine if there is any change in lean body mass 20 weeks
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