Aspirin Twice Daily in Diabetic Patients With Coronary Artery Disease

Status Completed

Clinical Trial Summary

The aim of the study is to evaluate platelet function variations according to the delay since last aspirin intake (12 vs 24 hours)in a population of diabetic patients with previous Coronary Artery Disease.

Clinical Trial Description

We have previously demonstrated that there was a time-dependant efficacy of aspirin on platelet function. In this study, we investigate platelet function (fundamental research) according to the delay since last aspirin intake (12 vs 24 hours)in a population of diabetic patients with previous Coronary Artery Disease routinely treated with aspirin. In order to eliminate any variation linked to a cumulative dose effect of aspirn, platelet function is assessed 24 hours after a single 150 mg aspirin intake or 12 hours after a 75 mg aspirin intake given twice per day (corresponding to the same total dose of 150 mg /day). Light transmission aggregometry triggered by arachidonic acid 0.5mg/mL (LTA-AA) is the main endpoint of the study (intensity and velocity of agregation following exposure to arachidonic acid 0.5 mg/ml). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01617031
Study type	Observational
Source	Hopital Lariboisière
Contact
Status	Completed
Phase	Phase 4
Start date	September 2010
Completion date	May 2012

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