View clinical trials related to Diabetes Mellitus, Type 2.
Filter by:This study is conducted in Asia. The aim of this observational study is to evaluate current status of diabetes management, control, complications in diabetic subjects in Asia.
The purpose of this study is to determine the safety and efficacy of albiglutide in subjects with type 2 diabetes
The primary purpose was to assess, in diabetic patients without diabetic retinopathy and control subjects, color vision, contrast sensitivity, electroretinography, and flicker-induced vasodilatation using the Dynamic Vessel Analyzer, in order to specify the earliest impaired retinal cells in diabetes, and gain more insight into diabetic retinopathy pathogenesis.
A study to determine the safety and efficacy of albiglutide in subjects with type 2 diabetes.
The purpose of this study is to determine if albiglutide is safe and effective in the treatment of type 2 diabetes.
Objectives: - To conduct a genome-wide association study (GWAS) to identify susceptibility genetic variants for diabetes among Han Chinese. - To conduct resequencing of positional candidate gene/loci to identify likely functional variants in a subset of the cohort. - To conduct replication studies of the top-100 scoring variants in three independent African and European ancestry samples. - To investigate whether diabetes-associated variants discovered in European populations increase diabetes risk in Han Chinese. Eligibility: - Patients 25 years of age with newly diagnosed T2D in Suizhou, China. Control subjects are nondiabetics, age and ethnically matched to patients. Design: - The study design for both patients and controls consists of the following steps: - Discuss informed consent process and obtain signed informed consent form. Informed consent will be administered by trained clinic staff. - Assign study ID (barcode) - Administer questionnaires - Obtain spot urine sample - Measure blood pressure - Obtain anthropometric measurements including body composition - Perform finger prick for blood glucose level - Obtain venous blood samples - Perform eye examination - On the following day, perform confirmatory blood glucose for the small subset of participants requiring confirmation of previous test result - DNA extraction of stored samples will be done at either the National Institutes of Health or the laboratory in China. - GWAS will be conducted using publicly available software packages.
Preliminary studies have shown that people with diabetes who undergo heart surgery may have a higher risk of developing cognitive functioning problems, including memory problems, than people without diabetes who undergo heart surgery. Among people with diabetes, however, those who control their blood sugar levels in a more intensive way during and after heart surgery may have better neurological outcomes than those who use a standard method of controlling their blood sugar levels. This study will compare the effectiveness of using a traditional method of blood sugar control versus a more intensive method of blood sugar control during and after heart surgery for improving neurological outcomes in people with diabetes.
This study is conducted in Asia. The aim of this observational study is to evaluate current status of diabetes management, control and complications in diabetic subjects in Asia.
Bariatric surgery can lead to improvement or even resolution of type 2 diabetes in about 80% of patients submitted to Roux-en-Y gastric bypass (RYGP). Otherwise, many patients experienced no resolution of their diabetes despite massive surgical-induced weight loss. There appears to be a variable response to surgery depending on surgical and patient factors. To explore potential factors affecting diabetes outcomes after RYGP, this study is proposed to make a description of effects of surgical procedures on incretin, insulin production and sensitivity and a comparison between patients with or without remission of Type 2 Diabetes.
Ileal interposition shifts a segment of ileum proximally to achieve maximal meal stimulated Glucagon-Like Peptide-1 secretion and coupled with a limited/complete sleeve gastrectomy (depending on the Body Mass Index), for Ghrelin reduction, helps in achieving good glycemic control in Type 2 Diabetes patients.