HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2 — HEATBED2  

Depression Clinical Trial

Official title: HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2

Status Recruiting

Clinical Trial Summary

This randomized two-arm intervention trial administers 8 weekly cognitive behavioral therapy (CBT) sessions and 4 bi-weekly active whole-body hyperthermia (active WBH) sessions or 4 bi-weekly sham WBH sessions to adults aged 18 years or older with major depressive disorder (MDD).

Clinical Trial Description

Major Depressive Disorder afflicts more than 300 million people worldwide and is the leading cause of life years lost to disability. Current treatments have important limitations in efficacy and, in the case of medication, substantial side-effects. There is thus a compelling need for additional effective, well-tolerated treatments. One such potential treatment is whole-body hyperthermia (WBH). The investigators hypothesize that active WBH may be particularly effective in combination with cognitive behavioral therapy (CBT), an established treatment for depression. This randomized two-arm trial will pilot and optimize procedures for randomizing participants to receive CBT (8 weekly sessions) and 4 bi-weekly whole-body hyperthermia (active WBH) or 4 bi-weekly sham WBH sessions. This work holds important promise to improve treatment of depression and advance understanding of the role of integrated mind-body therapies for mood disorders. ;

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Fever
• Hyperthermia
• Major Depressive Disorder

• NCT number: NCT05708976
• Study type: Interventional
• Source: University of California, San Francisco
• Contact: Anoushka Chowdhary, BA
• Phone: 415 514 8445
• Email: heatbed@ucsf.edu
• Status: Recruiting
• Phase: N/A
• Start date: February 15, 2023
• Completion date: September 30, 2024