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NCT ID: NCT03436251 Recruiting - Clinical trials for Cervical Intraepithelial Neoplasia

Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias

HPV
Start date: January 22, 2018
Phase: N/A
Study type: Interventional

Human papillomavirus(HPV) infect epithelial cells and have the capacity to stimulate cell abnormal hyperplasia, especially by those high-risk HPV types. HPV vaccine primarily targeting HPV6/11/16/18 has been available and makes it possible to prevent cervical cancer. However, a large population was left unvaccinated, specifically for those aged ones. In clinic, patients harboring high-risk HPV is quite prevalent in China or other developing nations. Removing the virus and prevention of malignant transformation is required. Mild local Hyperthermia with a certain temperature range has been successfully used in the treatment of some diseases. It has been utilised in the treatment of some neoplasm, fungal and HPV infections. Investigators' study found that local hyperthermia at 44°C could cleared HPV in more than half of the patients with plantar warts. Investigators also note the fact that in patients with multiple lesions, the clearance of the target lesion is commonly followed by clearance of other distant lesions, a phenomenon suggesting that local hyperthermia could aid in establishing a specific immune response to eliminate HPV.So the purpose of the study is to evaluation local hyperthermia in the treatment of cervical intraepithelial neoplasias grade I and II after 3 months, with positive high-risk type HPVs, and patients with positive testing for high risk HPVs. Appropriate control arms were designed for different conditions.

NCT ID: NCT03434795 Completed - Clinical trials for Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy

Distinction Risk of Severe Infection in Febrile Neutropenia After Chemotherapy

Start date: May 2012
Phase: N/A
Study type: Observational

Evaluate the reproducibility and validate a posteriori a new rule of clinical decision on a multi-center population of children with a post-chemotherapy febrile neutropenia

NCT ID: NCT03429738 Completed - Fever Clinical Trials

Single-Dose Bioavailability Study of Two Formulations of Ibuprofen and Pseudoephedrine Hydrochloride Tablets

Start date: April 27, 2014
Phase: Phase 1
Study type: Interventional

Evaluation of the comparative bioavailability between two oral formulations containing ibuprofen 200 mg and pseudoephedrine 30 mg after a single dose in healthy subjects under fasting conditions.

NCT ID: NCT03429387 Recruiting - Clinical trials for Acute Myeloid Leukemia

PET/CT and Bacterial/Fungal PCR in High Risk Febrile Neutropenia

PIPPIN
Start date: January 8, 2018
Phase: N/A
Study type: Interventional

Patients with acute leukaemia requiring induction or consolidation chemotherapy and those requiring a haematopoietic stem cell transplant are at high risk of fever and infection when they have low white cell counts (neutropenic fever). The causes of neutropenic fever are frequently unknown and patients are treated with broad antibiotics, without a clear target to what is being treated. This study will prospectively enroll patients who are receiving chemotherapy for acute leukaemia or for a stem cell transplant and compare the diagnostic utility of bacterial and fungal PCR performed directly off blood drawn, to the standard blood culture. Patients who have persistent fever after 72 hours of antibiotics will then be randomized to have either the interventional scan (PET/CT) or the conventional scan (standard CT) to look for a source of infection. Diagnostic yield, change in management and outcomes will be compared between arms.

NCT ID: NCT03393858 Recruiting - Cancer Clinical Trials

Combination of Immunotherapy and Hyperthermia in Advanced Malignant Mesothelioma

Start date: December 1, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to investigate the clinical efficacy and toxicity of anti-PD-1 monoclonal antibody plus autologous dendritic cells-cytokine induced killer cell (DC-CIK) immunotherapy combined with hyperthermia in advanced malignant mesothelioma patients.Furthermore,to characterize response to therapy,the investigators intent to explore the predictive biomarker for this regimen.

NCT ID: NCT03371693 Active, not recruiting - Ovarian Cancer Clinical Trials

Cytoreductive Surgery(CRS) Plus Hyperthermic Intraperitoneal Chemotherapy(HIPEC) With Lobaplatin in Advanced and Recurrent Epithelial Ovarian Cancer

HIPECOV
Start date: September 30, 2017
Phase: Phase 3
Study type: Interventional

A phase III prospective study with the primary objective to compare the efficacy and safety of HIPEC( Hyperthermic Intraperitoneal Chemotherapy). The target population for this study is patients with primary or recurrence ovarian, peritoneal or fallopian tube cancers undergoing CRS( Cytoreductive Surgery). Patients will be divided into two groups. Group A will undergo CRS plus HIPEC and then go on to receive standard platinum-based combination doublet intravenous chemotherapy. Group B will undergo CRS and then go on to intravenous chemotherapy.

NCT ID: NCT03370588 Not yet recruiting - Colon Cancer Clinical Trials

The Influence of Perioperative Administration of Dexmedetomidine on Inflammation Response and Postoperative Outcomes in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cytoreductive Surgery; Double Blind Randomized Controlled Trial

Start date: December 2017
Phase: N/A
Study type: Interventional

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) has been reported to be an effective treatment approach for peritoneal cancer, however, the stress response to HIPEC is major neuroendocrine and cytokine response, which has been considered as the homeostatic defense mechanism. Recently, dexmedetomidine has been suggested to exhibit anti-inflammatory properties. This study was designed to evaluate the effect of perioperative administration of dexmedetomidine on inflammation response and postoperative outcomes in patients undergoing hyperthermic intraperitoneal chemotherapy (HIPEC) cytoreductive surgery.

NCT ID: NCT03364907 Not yet recruiting - Clinical trials for Peritoneal Carcinomatosis

Clinical Pharmacology of Platinum-based Hyperthermic Intraperitoneal Chemotherapy

GUTOX
Start date: March 1, 2018
Phase: N/A
Study type: Observational

Currently, there is a lack of knowledge on the effect of additional flushing after HIPEC on tumour platinum exposure, systemic platinum exposure and platinum concentration in drain exudate and thereby personal exposure. Therefore the investigators want to perform a study to investigate the effect of flushing after HIPEC on tumour exposure, systemic exposure and on wound exudate concentration.

NCT ID: NCT03364257 Not yet recruiting - Infection Clinical Trials

iDTECT Blood Performance for the Identification of Viral or Bacterial Pathogens in Febrile Neutropenic Patients

IDENTIFY
Start date: January 15, 2018
Phase: N/A
Study type: Observational

Prospective, multicentre French observational study assessing the performance and medico-economic utility of iDTECT Blood versus conventional microbiologic diagnosis in patients with febrile neutropenia

NCT ID: NCT03360656 Recruiting - Fever Clinical Trials

Transnasal Induction of Normothermia in Febrile Stroke Patients

Start date: January 16, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate safety and performance of the COOLSTAT® Transnasal Thermal Regulating Device in reducing temperature in a population of febrile subjects who meet the inclusion/exclusion criteria.