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Clinical Trial Summary

The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established intermittent thetaburst rTMS (iTBS) treatment for treatment resistant depression (TRD).


Clinical Trial Description

In this multi-centre, triple-blinded, non-inferiority trial 420 patients with TRD will be recruited at two academic centres (UBC, CAMH). Patients will be randomised to receive either iTBS or LFR for 30 sessions. The primary outcome will be the improvement on a depression scale. Secondary outcome will be improvement of suicidal ideation. A secondary aim is to test the predictive capacity of a novel, easy to implement heart rate based biomarkers (i.e. heart rate variability). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04999553
Study type Interventional
Source University of British Columbia
Contact Afifa Humaira, BSc
Phone 604-827-1361
Email afifa.humaira@ubc.ca
Status Recruiting
Phase N/A
Start date November 8, 2021
Completion date February 1, 2026

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