Depression Clinical Trial
Official title:
The Impact of Palliative Care on Quality of Life, Anxiety, and Depression in Patients With Idiopathic Pulmonary Fibrosis
The purpose of this study is to evaluate the effects of adding a palliative care intervention
for patients with idiopathic pulmonary fibrosis (IPF) to current standard of care.
Palliative care is comprehensive, coordinated interdisciplinary care for patients and
families facing a potentially life-threatening illness. This consists of specially trained
teams of professionals including physicians, nurses, social workers, and chaplains that
provide care and support in inpatient and outpatient settings. While the specific assistance
and support provided by the Palliative Care Service depends on individual patient and family
needs and preferences, it may include:
1. Pain and symptom management
2. Psychosocial and spiritual support
3. Assistance with treatment choices
4. Help in planning for care in the community
Idiopathic pulmonary fibrosis (IPF) is a progressive and heterogeneous fibrotic lung disease.
It is universally fatal, with an average time to death between two to five years.
Patients with IPF experience significantly diminished quality of life and increased symptom
burden. Besides dyspnea, cough, fatigue, and deconditioning, patients with IPF experience
significant depression and anxiety. The benefit of palliative care has been demonstrated in
several other diseases, notably, in metastatic lung cancer. Patients with metastatic lung
cancer who were seen by palliative care at the time of their diagnosis and throughout their
disease course were found to have increased survival, improved quality of life, and received
less aggressive care at the end of their life. This finding has prompted significant research
in the role of palliative care in other diseases, including chronic lung disease. A
non-blinded, randomized trial of a multi-disciplinary breathlessness service intervention in
patients with advanced disease including cancer, chronic obstructive lung disease (COPD),
interstitial lung disease (ILD), and congestive heart failure demonstrated improvement in
breathlessness, anxiety, and even survival. Specific Aim 1: Determine if quality of life is
improved with a palliative care intervention. Specific Aim 2: Determine if depression and
anxiety symptoms are decreased with a palliative care intervention. Secondary aims include an
examination of pulmonary function tests (PFT), number of hospitalizations, and overall
mortality as an effect of a palliative care intervention.
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