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NCT ID: NCT05541497 Completed - Smoking Cessation Clinical Trials

Varenicline for Treatment of E-cigarette Dependence

Start date: November 4, 2022
Phase: Phase 2
Study type: Interventional

Varenicline is used to treat tobacco use dependence. It helps reduce cravings for tobacco use and decreases the pleasurable effects of cigarettes and other tobacco products. Varenicline has been proven to reduce the desire to smoke cigarettes. This study aims to test whether it shows a similar benefit for individuals who vape and are interested in quitting.

NCT ID: NCT05541471 Completed - Pain Clinical Trials

A Study to Evaluate the Pharmacokinetic Drug-drug Interactions Between VX-548, Midazolam, and Digoxin

Start date: September 22, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the pharmacokinetics of midazolam and digoxin in the absence and presence of VX-548.

NCT ID: NCT05541328 Completed - Clinical trials for Diffuse Large B-cell Lymphoma

Comparison of Clinical Outcomes Among Patients Treated With Tisagenlecleucel

Start date: February 3, 2020
Phase:
Study type: Observational

This is a non-interventional, retrospective cohort study using the Flatiron Health Research Database (FHRD) and data from the single-arm phase II JULIET clinical trial (NCT02445248).

NCT ID: NCT05541315 Completed - Healthy Clinical Trials

A Single Ascending Dose Study of JNJ-88260237 in Healthy Participants

Start date: September 14, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of a single oral dose of JNJ-88260237 in healthy participants

NCT ID: NCT05541055 Completed - Insomnia Disorder Clinical Trials

Digital CBT-I for Insomnia Disorder

CrEDIT
Start date: November 8, 2022
Phase: N/A
Study type: Interventional

This study will examine the effectiveness of digital CBT-I versus sleep hygiene education in reducing insomnia severity, sleep onset latency, and wake after sleep onset in those with insomnia disorder.

NCT ID: NCT05541003 Completed - Obesity Clinical Trials

Understanding the Role of Gut Microbiota in Hyperphagia in Prader-Willi Syndrome

PWSGUT
Start date: January 6, 2023
Phase: Phase 2
Study type: Interventional

This study aims to use a high-fiber supplementation, an intervention known to create shifts in the gut microbiota towards a healthier structure, to explore the relationship between gut microbiota, appetite control and feeding behavior in PWS patients.

NCT ID: NCT05540717 Completed - Clinical trials for Seasonal Allergic Rhinitis

Efficacy and Safety of PQ Grass in Subjects With Seasonal Allergic Rhinitis and/or Rhinoconjunctivitis Induced by Grass Pollen

Start date: October 11, 2022
Phase: Phase 3
Study type: Interventional

The PQGrass306 (G306) clinical trial is the pivotal Phase III efficacy clinical trial of PQ Grass. The aim of the G306 pivotal clinical trial is to confirm the efficacy and safety of the optimal effective dose of PQ Grass 27600 SU. This will be determined through the measurements of the effect of PQ Grass on the symptoms of seasonal allergic rhinitis (SAR)/rhinoconjunctivitis and the use of relief medications to control these symptoms during the peak grass pollen season (GPS).

NCT ID: NCT05540522 Completed - Influenza, Human Clinical Trials

A Study to Evaluate a Modified RNA Vaccine Against Influenza in Adults 18 Years of Age or Older

Start date: September 12, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase 3, randomized, observer-blinded study to evaluate the efficacy, safety, tolerability, and immunogenicity of a single dose of a quadrivalent influenza modRNA vaccine compared to licensed inactivated influenza vaccine in healthy adults 18 years of age and older.

NCT ID: NCT05540457 Completed - Clinical trials for End Stage Renal Disease

Evaluation of Non-Invasive Continuous vs Intermittent BloodPressure Monitors in Maintenance Dialysis (BP Dialysis)

Start date: September 22, 2022
Phase: N/A
Study type: Interventional

Prospective, single center, open label, non-randomized, post-market study of the Tablo Hemodialysis System and VitalStream Monitor in participants with End-Stage KidneyDisease undergoing In-Center Hemodialysis.

NCT ID: NCT05540405 Completed - PreDiabetes Clinical Trials

Effects of Bitter Melon on Cardiometabolic Health

Start date: January 24, 2023
Phase: N/A
Study type: Interventional

The objectives of this study are to assess the effects of a bitter melon product at two doses, compared to control, on indicators of cardiometabolic health among men and women with prediabetes.