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NCT ID: NCT05776108 Completed - HIV Infections Clinical Trials

A Study to Assess the Food Effect and the Relative Bioavailability of the Cabotegravir (CAB) Pediatric Dispersible Tablet (DT) Formulation

Start date: March 23, 2023
Phase: Phase 1
Study type: Interventional

This study will assess the relative bioavailability of the CAB DT formulation relative to that of the CAB IR formulation and to assess the effect of food on the CAB DT formulation.

NCT ID: NCT05775744 Completed - Clinical trials for Postpartum Preeclampsia

Management of Postpartum Preeclampsia

MOPP
Start date: March 28, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to assess the effect of a lower treatment threshold for antihypertensive medication and tighter blood pressure control, using remote blood pressure monitoring, on reducing Emergency Room visits for our postpartum patients with hypertensive disease.

NCT ID: NCT05775601 Completed - Radiation Exposure Clinical Trials

18F-LY3950321-01 Biodistribution and Safety Study

Start date: February 28, 2023
Phase: Early Phase 1
Study type: Interventional

18F-LY3950321 (also known as 18F-MNI-1256) is a radiolabeled positron emission tomography (PET) tracer targeting granzyme B. The overall goal of this protocol is to evaluate the safety, tolerability, and radiation dosimetry of 18F-LY3950321.

NCT ID: NCT05775549 Completed - Clinical trials for Advanced Ovarian Cancer

A Study to Characterize the Outcomes of Olaparib Maintenance Monotherapy in Newly Diagnosed BRCAwt Ovarian Cancer

FLAME
Start date: July 10, 2023
Phase:
Study type: Observational

This study will collect the data from existing patient medical records at US cancer centers. The study will include patients with BRCAwt ovarian cancer who have been prescribed first line (1L) olaparib maintenance treatment.

NCT ID: NCT05774470 Completed - Clinical trials for Neonatal Bradycardia

Bradycardia Recognition and Detection in Young Infants Part-I

BRADY-I
Start date: April 22, 2023
Phase:
Study type: Observational

This prospective cohort study will determine the diagnostic accuracy of the Owlet OSS 3.0 monitor for the detection of episodes of bradycardia and/or hypoxemia among infants.

NCT ID: NCT05773794 Completed - Polyphenols Clinical Trials

Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans

Start date: February 6, 2023
Phase: N/A
Study type: Interventional

This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of dietary polyphenols (soymilk, green tea, and blueberry) in humans after a single dose of dietary flavonoids.

NCT ID: NCT05773703 Completed - Prostate Cancer Clinical Trials

Exploratory PK and Imaging Study of PSMA-Targeted Trillium Compounds and PTI-122 in Metastatic Prostate Cancer

Start date: December 8, 2022
Phase: Early Phase 1
Study type: Interventional

Exploratory study in adult males with metastatic prostate cancer intended to characterize the pharmacokinetics and biodistribution of PSMA-Targeted [In-111]-Labeled Trillium Compounds with and without the cytoprotective agent PTI-122. Up to 36 eligible subjects will be enrolled. Additional subjects may be enrolled if there is insufficient data for evaluation, for example if the original study subjects do not complete required imaging studies for reasons unrelated to adverse events. Up to four PSMA-Targeted [In-111]-Labeled Trillium Compounds will be evaluated. Each compound will be evaluated first without the cytoprotective agent, PTI-122, then the [In-111]-labeled Trillium Compound may be co-administered with PTI-122.

NCT ID: NCT05773053 Completed - Platysma Prominence Clinical Trials

A Study of NT 201 Doses in the Treatment of Platysma Prominence

PAOLA
Start date: March 22, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of NT 201 in adults with moderate to severe platysma prominence.

NCT ID: NCT05773027 Completed - Alcohol Drinking Clinical Trials

Integrated Alcohol and Sexual Assault Intervention for College Men

Start date: October 17, 2013
Phase: N/A
Study type: Interventional

This research will evaluate a new intervention that integrates evidence-based alcohol intervention strategies and promising sexual assault prevention strategies with the goal of decreasing sexual aggression among men who report heavy drinking; a particularly high risk group. Specifically, this study will conduct a randomized controlled pilot trial with college men who report heavy drinking to demonstrate the feasibility and acceptability of the proposed intervention. The main questions the study will answer are: 1) what is the feasibility of the recruitment plans, research design, intervention training methods, and delivery of the program?; and 2) does the intervention, relative to a mindfulness-based control condition, produce reductions in the quantity and frequency of alcohol use, perpetration of sexual aggression, and attitudes associated with sexual aggression over the 2- and 6-month follow-up. Follow-up assessments are completed at 2- and 6-months following the program. The intervention is compared to the mindfulness-based control group.

NCT ID: NCT05772936 Completed - Clinical trials for Stroke, Cerebrovascular

Reactive Standing Balance Step Training Post Stroke

Start date: January 22, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the effectiveness of reactive step training on the timing and frequency of perturbation induced paretic leg stepping in persons post stroke. The study will consist of one or six one-hour training sessions and a pre and post visit each lasting up to two hours at our downtown Chicago location.