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NCT ID: NCT04613596 Recruiting - Clinical trials for Advanced Non-Small Cell Lung Cancer

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Start date: December 2, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates for first-line treatment. The Phase 3 portion of the study compares the efficacy of adagrasib in combination with pembrolizumab versus pembrolizumab in patients with unresectable, locally advanced or metastatic nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS >=50% and who are candidates for first line treatment.

NCT ID: NCT04612998 Completed - Obesity Clinical Trials

Combined Spinal Epidural Anesthesia in Obese Patients Undergoing Cesarean Surgery

Start date: February 1, 2017
Phase: N/A
Study type: Interventional

This study investigated the maternal and fetal effects during performance of CSEA in the left lateral decubitus and sitting positions in obese pregnant women undergoing elective cesarean section.

NCT ID: NCT04612959 Completed - Infertility, Female Clinical Trials

Effect of Psychosexual Caring Program on Sexual Well-being of Infertile Women

Start date: June 11, 2020
Phase: N/A
Study type: Interventional

The present study aims to examine the effect of the psychosexual caring program on the sexual well-being of infertile women.

NCT ID: NCT04612751 Recruiting - Clinical trials for Advanced or Metastatic NSCLC

Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer

TROPION-Lung04
Start date: February 2, 2021
Phase: Phase 1
Study type: Interventional

This study will assess safety, tolerability, and treatment activity of datopotamab deruxtecan (Dato-DXd) in combination with immunotherapy in participants with advanced or metastatic non-small cell lung cancer (NSCLC).

NCT ID: NCT04612543 Completed - Clinical trials for Dental Caries Extending Into Dentin

Clinical Evaluation of Extensive Direct Composite Restorations With Polyethylene Fiber

Start date: February 10, 2019
Phase: N/A
Study type: Interventional

The aim of this clinical trial was to compare the clinical performances of composite resin restorations with/without the polyethylene fiber to the first permanent molar teeth with extensively carious pediatric patients. A total of 75 restorations with (FC; n=38)or without (C; n=37) fiber were placed in the first permanent molar teeth. Restorations were evaluated at baseline-6-12-18 months according to the modified-USPHS criteria. Data were analyzed with Chi-Square and Cochran's Q (p<0.05).

NCT ID: NCT04611984 Completed - Tooth Movement Clinical Trials

OC and ICTP in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Treatment

Start date: March 2013
Phase: N/A
Study type: Interventional

The aim of this study was to evaluate the tooth movement with and without piezocision with regard to the levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen in the gingival crevicular fluid.

NCT ID: NCT04611386 Completed - Clinical trials for Contrast Agents and Oral Factor Xa Inhibitor

The Effect of Contrast Agents on the Anticoagulant Properties of Oral Factor Xa Inhibitors

Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to evaluate the effect of iohexol as a contrast agent on the anticoagulant activity of oral factor Xa inhibitors.

NCT ID: NCT04610151 Completed - Healthy Clinical Trials

The Effects of Guided Imagery on Postoperative Pain Management

Start date: April 1, 2018
Phase: N/A
Study type: Interventional

This study was conducted to determine the effects of guided imagery on postoperative pain management.

NCT ID: NCT04609904 Recruiting - Asthma Clinical Trials

Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (LOGOS)

LOGOS
Start date: March 1, 2021
Phase: Phase 3
Study type: Interventional

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.

NCT ID: NCT04609722 Completed - Anxiety Clinical Trials

Effect of Solution-Focused Support Program on Anxiety Levels of Parents During the COVID-19 Pandemic

Start date: July 1, 2020
Phase: N/A
Study type: Interventional

In this research, it was aimed to determine the anxiety levels of parents in the Covid-19 pandemic and to examine the effects of the Solution-Focused Support Program, which is planned to be given to parents with high anxiety levels.