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NCT ID: NCT00282724 Completed - Clinical trials for Ichthyosis, Lamellar

Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis

Start date: January 2006
Phase: Phase 2/Phase 3
Study type: Interventional

Lamellar ichthyosis is a congenital disease of the skin with a generalized scaling. The primary activity of liarozole is considered to be the inhibition of the degradation of a substance called retinoic acid, which is the principal endogenous regulator of growth and differentiation of epithelial tissues in mammals. The current study intends to evaluate the efficacy and safety in patients with lamellar ichthyosis.

NCT ID: NCT00282178 Completed - Obesity Clinical Trials

Double-Blind Randomized Cross-Over Trial Comparing Metabolic Effects of Candesartan, Hydrochlorothiazide and Placebo

Start date: April 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the effect of a 12-week candesartan treatment compared with hydrochlorothiazide on insulin sensitivity assessed with hyperinsulinemic euglycemic clamp.

NCT ID: NCT00281554 Completed - Atrial Fibrillation Clinical Trials

Study of RSD1235 to Evaluate Safety in Patients With Atrial Fibrillation

ACT 4
Start date: October 2005
Phase: Phase 3
Study type: Interventional

This study is designed to determine the safety of RSD1235 in patients with atrial fibrillation.

NCT ID: NCT00280709 Completed - Pancreatic Cancer Clinical Trials

Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction

Start date: January 2006
Phase: Phase 4
Study type: Interventional

The primary purpose is to compare patency of two different types of biliary metal stents, i.e. covered versus uncovered Nitinella metal stent. Secondary purposes are to determine frequency of complications in the two groups, e.g. cholecystitis, pancreatitis, and cholangitis.

NCT ID: NCT00280059 Completed - Epilepsy, Partial Clinical Trials

Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy

Start date: August 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess whether Lyrica is a safe and effective treatment for partial epilepsy in comparison with an established treatment, Lamictal.

NCT ID: NCT00279318 Active, not recruiting - Clinical trials for Type 1 Diabetes Mellitus

TEDDY - The Environmental Determinants of Diabetes in the Young

Start date: September 2004
Phase:
Study type: Observational

The long-term goal of the TEDDY study is the identification of infectious agents, dietary factors, or other environmental agents, including psychosocial factors which trigger T1DM in genetically susceptible individuals or which protect against the disease. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1DM.

NCT ID: NCT00279045 Completed - Clinical trials for Diabetes Mellitus, Type 2

Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide

Start date: January 3, 2000
Phase: Phase 3
Study type: Interventional

The study will compare and evaluate the effects of long-term treatment of monotherapy with rosiglitazone, metformin and glyburide/glibenclamide on the improvement and maintenance of glycemic control in patients with recently diagnosed type 2 diabetes mellitus.

NCT ID: NCT00278980 Completed - Clinical trials for Diabetes Mellitus, Type 1

Effect of C-Peptide on Diabetic Peripheral Neuropathy

Start date: October 2003
Phase: Phase 2
Study type: Interventional

The aim of the study is to investigate the effect of C-peptide administration on nerve function in patients with type 1 diabetes and peripheral sensory neuropathy.

NCT ID: NCT00276757 Completed - Clinical trials for Childhood Langerhans Cell Histiocytosis

Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis

Start date: April 2001
Phase: N/A
Study type: Interventional

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of Langerhans cell histiocytosis, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may be an effective treatment for Langerhans cell histiocytosis. PURPOSE: This randomized clinical trial is studying combination chemotherapy to see how well it works in treating young patients with Langerhans cell histiocytosis.

NCT ID: NCT00275457 Completed - Clinical trials for Restless Legs Syndrome

Efficacy and Safety of Pramipexole (PPX) in Moderate to Severe Idiopathic Restless Legs Syndrome (RLS) Patients

Start date: October 2002
Phase: Phase 3
Study type: Interventional

To evaluate safety and efficacy of pramipexole in the treatment of patients suffering from moderate to severe RLS over 6 weeks under double blinded conditions followed by a 46 week open label or double blind extension.