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NCT ID: NCT00864552 Completed - Hemophilia A Clinical Trials

International PMS Study - KOGENATE Bayer

Start date: December 2002
Phase: N/A
Study type: Observational

To evaluate long-term safety (primarily by recording adverse events including inhibitors), efficacy and patient acceptance of KOGENATE Bayer in home treatment either on prophylaxis or on demand. To evaluate both safety and efficacy with respect to lot variability, in particular regarding lot-groups formulated with or without fix between.

NCT ID: NCT00864097 Terminated - Osteoarthritis Clinical Trials

Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip

Start date: August 11, 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the analgesic efficacy and safety of tanezumab added on to diclofenac SR in patients with osteoarthritis of the knee or hip currently experiencing partial benefit from, and are tolerating, diclofenac 150 mg/day therapy.

NCT ID: NCT00863746 Completed - Carcinoma Clinical Trials

A 3rd/4th Line Placebo-controlled Trial of Sorafenib in Patients With Predominantly Non Squamous Non-Small Cell Lung Cancer (NSCLC).

MISSION
Start date: April 2009
Phase: Phase 3
Study type: Interventional

The purpose of the study is to see if sorafenib plus best supportive care (i.e. in addition to the non-cancer treatments patients would normally receive) is an effective treatment for lung cancer compared to best supportive care alone. The safety and tolerability of the two treatment groups will also be compared. The goal of the study is to test the ability of sorafenib to improve survival compared to best supportive care alone.

NCT ID: NCT00863681 Completed - Clinical trials for Hypertension, Pulmonary

BAY63-2521:Long-term Extension Study in Patients With Pulmonary Arterial Hypertension

PATENT-2
Start date: March 12, 2009
Phase: Phase 3
Study type: Interventional

Patients who have completed the 12 weeks treatment of the PATENT-1 trial (study number 12934) will be asked to participate in this long term extension study with BAY63-2521.

NCT ID: NCT00863655 Completed - Breast Cancer Clinical Trials

Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole

BOLERO-2
Start date: June 2009
Phase: Phase 3
Study type: Interventional

There are no treatments specifically approved after recurrence or progression on a non steroidal aromatase inhibitors (NSAI). In light of the need for new treatment options for postmenopausal women after failure of prior NSAI therapy, the purpose of this Phase III study is to compare efficacy and safety of a treatment with exemestane + everolimus to exemestane + placebo in postmenopausal women with estrogen receptor positive locally advanced or metastatic breast cancer refractory to NSAI.

NCT ID: NCT00863161 Completed - Reflux Clinical Trials

Renal Impairment Study

Start date: March 2009
Phase: Phase 1
Study type: Interventional

The purpose of this study is to see how quickly AZD3355 is taken up in to the blood and leaves the blood in people with normal kidney function or with different degrees of reduced kidney function.

NCT ID: NCT00862121 Terminated - Crohn´s Disease Clinical Trials

A Study With Pentasa in Patients With Active Crohn's Disease

PEACE
Start date: April 2009
Phase: Phase 3
Study type: Interventional

The purpose of this trial is to demonstrate that Pentasa administered as a 2 g morning dose and a 4 g evening dose is efficacious in active mild to moderate CD.

NCT ID: NCT00861809 Completed - Gastroparesis Clinical Trials

The Effect of Single Doses of the Motilin Receptor Agonist GSK962040 in Type I Diabetic Patients With Gastroparesis

Start date: June 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the pharmacodynamic effects (gastric emptying), safety, tolerability, and pharmacokinetics of single doses of GSK962040 in Type 1 diabetic patients with gastroparesis.

NCT ID: NCT00861120 Completed - Clinical trials for Epithelial Ovarian Cancer

Panitumumab and Pegylated Liposomal Doxorubicin for Platinum-Resistant Epithelial Ovarian Cancer With KRAS Wild-type

PaLiDo
Start date: April 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the response rate in platinum-resistant, KRAS wild-type, ovarian cancer patients who are treated with pegylated liposomal doxorubicin (Caelyx®) in combination with biological treatment panitumumab (Vectibix®).

NCT ID: NCT00860821 Completed - Healthy Clinical Trials

A Methodology Study in Healthy Subjects to Evaluate the Effect of AZD8309 After Nasal Administration of Lipopolysaccharide (LPS)

Start date: March 2009
Phase: N/A
Study type: Interventional

The purpose of this methodology study is to evaluate the effect of AZD8309 on cells and inflammatory biomarkers in nasal lavage and blood after nasal challenge with lipopolysaccharide (LPS)