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NCT ID: NCT00891046 Completed - Clinical trials for Systemic Juvenile Idiopathic Arthritis

An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and Without Fever.

ß-SPECIFIC 3
Start date: September 2009
Phase: Phase 3
Study type: Interventional

This open-label extension study will permit patients with Systemic Juvenile Idiopathic Arthritis (SJIA) who previously were responsive to treatment with canakinumab and canakinumab treatment-naïve patients with active SJIA with and without fever to be retreated with 4 mg/kg s.c. every 4 weeks and assessed for continued efficacy and safety until discontinuation or when study CACZ885G2402 is in place at their study center or around March 2013, whichever occurs first. Patients who are steroid-free will be able to taper their canakinumab dose to 2 mg/kg s.c. every 4 weeks.

NCT ID: NCT00890890 Terminated - Alzheimer's Disease Clinical Trials

A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease

Start date: May 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and tolerability of BMS-708163 in patients with Prodromal Alzheimer's disease over a treatment period of a minimum of 104-weeks. In addition patients will be seen for safety visits at 4 and 12 weeks post treatment.

NCT ID: NCT00889876 Terminated - Clinical trials for Cardiovascular Diseases

Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for CVD Among Obese Adolescents

Start date: February 2009
Phase: N/A
Study type: Interventional

The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.

NCT ID: NCT00889863 Completed - Clinical trials for Systemic Juvenile Idiopathic Arthritis With Active Flare

Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)

ß-SPECIFIC 2
Start date: July 2009
Phase: Phase 3
Study type: Interventional

This two-part study assessed the sustained efficacy of canakinumab in the double-blind Part II and the ability to taper steroids in the open label Part I.

NCT ID: NCT00889486 Completed - Diabetes Mellitus Clinical Trials

Safety and Efficacy of Once-daily Oral Administrations of TZP-102 for Gastroparesis in Patients With Diabetes Mellitus

Start date: April 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effect of TZP-102 on gastric emptying rate, gastroparesis symptoms and health-related quality of life in diabetic patients with gastroparesis.

NCT ID: NCT00888225 Completed - Clinical trials for Lateral Epicondylitis

Tennis Elbow Trial

Epi-X
Start date: October 2003
Phase: N/A
Study type: Interventional

Epi-X is a multicentered randomized controlled clinical trial of chronic lateral epicondylitis with parallel group design and two phases. In the first phase physical exercise treatment is given in the intervention group and expectance in the reference group. In phase 2 eccentric exercise versus concentric is tested.

NCT ID: NCT00888186 Completed - Parkinson Disease Clinical Trials

Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics

DYSK-PD-2007
Start date: February 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.

NCT ID: NCT00887978 Completed - Clinical trials for Pulmonary Hypertension

Efficacy and Safety of Oral UT-15C Tablets to Treat Pulmonary Arterial Hypertension

FREEDOM-C2
Start date: June 2009
Phase: Phase 3
Study type: Interventional

This study is an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who are currently receiving approved therapy for their PAH (i.e., endothelin receptor antagonist and/or phosphodiesterase-5 inhibitor). Study visits will occur at 4 week intervals for 16 weeks with the key measure of efficacy being the 6-minute walk test. Study procedures include routine blood tests, medical history, physical exams, disease evaluation, and exercise tests. Patients who complete all assessments for 16-weeks will also be eligible to enter an open-label, extension phase study (FREEDOM - EXT).

NCT ID: NCT00887198 Completed - Prostate Cancer Clinical Trials

Abiraterone Acetate in Asymptomatic or Mildly Symptomatic Patients With Metastatic Castration-Resistant Prostate Cancer

Start date: April 28, 2009
Phase: Phase 3
Study type: Interventional

This is a phase 3 study to compare the clinical benefit of abiraterone acetate plus prednisone with placebo plus prednisone in asymptomatic or mildly symptomatic patients with metastatic castration-resistant prostate cancer (CRPC).

NCT ID: NCT00886769 Terminated - Clinical trials for Systemic Juvenile Idiopathic Arthritis

Single-dose Study to Assess Efficacy of Canakinumab (ACZ885) in Patients With Active Juvenile Idiopathic Arthritis (SJIA)

ß-SPECIFIC 1
Start date: July 2009
Phase: Phase 3
Study type: Interventional

This study assessed the initial efficacy and safety of canakinumab over a 4 week period in patients with systemic juvenile idiopathic arthritis (SJIA) having a flare. Response to treatment will be according to the adapted American College of Rheumatology(ACR)Pediatric 30 criteria at Day 15.