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NCT ID: NCT00288379 Completed - Asthma Clinical Trials

SMILDA - Symbicort®Turbuhaler® Allergan Challenge Study in Allergic Patients With Mild Asthma

Start date: October 2004
Phase: Phase 3
Study type: Interventional

To compare the effects of formoterol alone (Oxis® TurbuhalerÒ) and the fixed combination of formoterol and budesonide (Symbicort® TurbuhalerÒ) on airway responsiveness as a marker of inflammation, induced by repeated low-dose allergen challenge in allergic patients with mild asthma

NCT ID: NCT00287092 Completed - Tetanus Clinical Trials

Comparison of Safety and Immunogenicity of Pediacel™ and Infanrix™ IPV+Hib (Penta) Given in a 3 Dose Schedule in Infants

Start date: February 2006
Phase: Phase 3
Study type: Interventional

Pediacel™ is currently licensed in the UK for use as a 3 dose regimen for the active immunisation of infants against Diphtheria, Tetanus, Pertussis, Poliomyelitis and invasive infections caused by Haemophilus influenzae type b. However there are currently no clinical data supporting the use of Pediacel™ using a 3, 5, and 12 months of age vaccination schedule. This study is designed to provide safety and immunogenicity data to support the use of Pediacel™ according to a 3, 5, and 12 months schedule.

NCT ID: NCT00286897 Completed - Parkinson's Disease Clinical Trials

The Efficacy, Safety and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations

Start date: February 2006
Phase: Phase 3
Study type: Interventional

Patients will be randomised to receive either placebo or the study drug for a period of 30 weeks, in addition to their standard Parkinsonian medications. During the first 8 weeks, the patient's levodopa doses may be adjusted if necessary by the investigator. For the remainder of the 22 weeks, all medications should be kept stable. Patients will be required to attend the clinic twice during the screening period and then a further 8 times during the treatment period. They will be required to complete home diaries where they will record their motor function. In addition, their doctor will assess their Parkinson's disease during the clinic visits. There will also be blood draws for safety and pharmacokinetic and pharmacogenomics evaluation. Following the treatment and assessment period, they will return to the clinic one month later for follow up.

NCT ID: NCT00285077 Completed - Alzheimer Disease Clinical Trials

Long-Term Safety Extension With SR57667B in Patients With Alzheimer's Disease

Start date: March 2004
Phase: Phase 2
Study type: Interventional

The primary objective is to assess the long term safety/tolerability of 4 mg/day of SR57667B in comparison to placebo in patients with mild-to-moderate Alzheimer's Disease (AD). A secondary objective is to describe the long term progression of Alzheimer's symptoms in patients treated by 4 mg/day of SR57667B.

NCT ID: NCT00282932 Completed - Clinical trials for Overactive Bladder (OAB)

Detrol LA In Men With Overactive Bladder.

Start date: January 2006
Phase: Phase 4
Study type: Interventional

An interventional active/placebo double blinded parallel randomized controlled study in which at 12 weeks of treatment, the primary endpoint of patient perception of bladder condition is measured along with associated safety and other secondary endpoints like bladder diary endpoints, quality of life and patient treatment satisfaction. Patients included in the study must have symptoms of OAB (frequency of at least 8 per day and Urgency of at least 1 episode per day confirmed by bladder diary). Patients are not eligible to enroll in the study if they have/had significant hepatic or renal disease, history of radiation treatment.

NCT ID: NCT00282724 Completed - Clinical trials for Ichthyosis, Lamellar

Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis

Start date: January 2006
Phase: Phase 2/Phase 3
Study type: Interventional

Lamellar ichthyosis is a congenital disease of the skin with a generalized scaling. The primary activity of liarozole is considered to be the inhibition of the degradation of a substance called retinoic acid, which is the principal endogenous regulator of growth and differentiation of epithelial tissues in mammals. The current study intends to evaluate the efficacy and safety in patients with lamellar ichthyosis.

NCT ID: NCT00282178 Completed - Obesity Clinical Trials

Double-Blind Randomized Cross-Over Trial Comparing Metabolic Effects of Candesartan, Hydrochlorothiazide and Placebo

Start date: April 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the effect of a 12-week candesartan treatment compared with hydrochlorothiazide on insulin sensitivity assessed with hyperinsulinemic euglycemic clamp.

NCT ID: NCT00281554 Completed - Atrial Fibrillation Clinical Trials

Study of RSD1235 to Evaluate Safety in Patients With Atrial Fibrillation

ACT 4
Start date: October 2005
Phase: Phase 3
Study type: Interventional

This study is designed to determine the safety of RSD1235 in patients with atrial fibrillation.

NCT ID: NCT00280709 Completed - Pancreatic Cancer Clinical Trials

Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction

Start date: January 2006
Phase: Phase 4
Study type: Interventional

The primary purpose is to compare patency of two different types of biliary metal stents, i.e. covered versus uncovered Nitinella metal stent. Secondary purposes are to determine frequency of complications in the two groups, e.g. cholecystitis, pancreatitis, and cholangitis.

NCT ID: NCT00280059 Completed - Epilepsy, Partial Clinical Trials

Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy

Start date: August 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess whether Lyrica is a safe and effective treatment for partial epilepsy in comparison with an established treatment, Lamictal.