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NCT ID: NCT01358994 Completed - Clinical trials for Type 2 Diabetes Mellitus

Metformin Treatment, Renal Function and Lactic Acidosis

Start date: January 2011
Phase:
Study type: Observational

From a central registry at the National Board of Health and Welfare in Sweden collect all patients in the city of Malmö prescribed metformin during two years. Glomerular filtration rate (eGFR) was estimated from the CKD-EPI formula (n=5408) and compared to a control material (n=2815) from the same town. All cases of severe lactic acidosis rendering ICU admission were also sought. The study hypothesis is that metformin is prescribed to patients with lower GFR than anticipated with very few cases of lactic acidosis registered.

NCT ID: NCT01358825 Completed - Hepatitis B Clinical Trials

Study to Evaluate Antibody Persistence in Children Previously Vaccinated With Infanrix Hexa™ or Infanrix-IPV/Hib™

Start date: May 30, 2011
Phase: Phase 4
Study type: Interventional

The aim of this study is to assess antibody persistence in infants who received three doses of Infanrix hexa™ (DTPa-HBV-IPV/Hib) or Infanrix-IPV/Hib™ (DTPa-IPV/Hib) at 3, 5 and 11 months of age in study NCT00307034.

NCT ID: NCT01358578 Completed - Clinical trials for Chronic Plaque Psoriasis

Safety and Efficacy of Secukinumab Compared to Etanercept in Subjects With Moderate to Severe, Chronic Plaque-Type Psoriasis

FIXTURE
Start date: June 2011
Phase: Phase 3
Study type: Interventional

This study will assess the safety and efficacy of secukinumab compared to placebo and etanercept in patients that have moderate to severe, chronic, plaque-type psoriasis.

NCT ID: NCT01357304 Completed - Hypertension Clinical Trials

10 Prescriptions an Hour. Group Treatment and Physical Activity Referral in a Primary Health Care Setting

10PAR
Start date: March 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the effects of group treatment including physical activity referral (PAR) on level of physical activity and quality of life in patients diagnosed with type 2 diabetes and/or hypertension in a primary health care setting

NCT ID: NCT01357239 Completed - Fragile X Syndrome Clinical Trials

Safety and Efficacy of AFQ056 in Adolescent Patients With Fragile X Syndrome

Start date: May 2011
Phase: Phase 2
Study type: Interventional

This Phase IIb study is designed to assess whether 3 doses of AFQ056 are safe and effective in treating the behavioral symptoms of Fragile X Syndrome.

NCT ID: NCT01357109 Completed - Clinical trials for Type 2 Diabetes Mellitus

Effect of Bosentan on Endothelial Function in Patients With Type 2 Diabetes

BANDY
Start date: November 2007
Phase: Phase 2
Study type: Interventional

The purpose of the study is to investigate if oral treatment with bosentan improves endothelium-dependent vasodilatation in patients with type 2 diabetes and microangiopathy.

NCT ID: NCT01355627 Completed - Clinical trials for Cerebrospinal Fluid Leaks

TASALL - TachoSil® Against Liquor Leak

Start date: April 2011
Phase: Phase 3
Study type: Interventional

The primary objective is to demonstrate superiority of TachoSil® compared to current practice as an adjunct in sealing the dura mater. The efficacy of the dura mater sealing must be evaluated post-operatively. The secondary objective is to evaluate the safety of TachoSil® as an adjunct in sealing the dura mater. The trial population will consist of 726 randomised (1:1) patients elected for skull base surgery. The trial duration consists of screening, surgery, efficacy follow-up after 7±1 weeks and safety follow-up 28±2 weeks after surgery.

NCT ID: NCT01354899 Completed - Critical Illness Clinical Trials

A Open Study to Evaluate the Performance of Dressing on Subject With High Risk of Skin Breakdown

Start date: May 2011
Phase: N/A
Study type: Observational

The rational for the study is to add a thin self-adherent dressing on critically ill patients. Evaluate if the dressing might protect the skin for further breakdown.Participants will be followed for the duration of hospital stay, an expected average of 5 days.

NCT ID: NCT01354184 Completed - Clinical trials for Abdominal Aortic Aneurysm

CRD007 for the Treatment of Abdominal Aorta Aneurysm (The AORTA Trial)

Start date: n/a
Phase: Phase 2
Study type: Interventional

This is an investigation of the efficacy and safety of CRD007 compared to placebo in the treatment of patients with abdominal aortic aneurysm.

NCT ID: NCT01354067 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Single Limb Resistance Training in Patients With Chronic Obstructive Pulmonary Disease (COPD)

COPD
Start date: May 2011
Phase: N/A
Study type: Interventional

The chronic airflow limitation in chronic obstructive pulmonary disease (COPD) patients resulting in increased dyspnea during physical activity restricts many COPD patients ability to perform exercises in general and whole-body exercises in particular. Single limb training performed as one-legged cycling has been shown effective in patients with COPD. This exercise regime results in less stress on the ventilatory system as training is executed using a simultaneously smaller muscle mass. However, the positive physiological effects of exercise training only occur in the involved muscle(s). To be of benefit for patients daily life, all relevant muscles should be included in exercise training. The aim of the current randomized controlled multicenter trial (RCT) is to determine the effects of high-repetitive single limb exercises (HRSLE) in combination with COPD specific patient education, compared to the COPD specific patient education alone in patients with moderate to very severe (stage II-IV) COPD.