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Abdominal Aortic Aneurysm clinical trials

View clinical trials related to Abdominal Aortic Aneurysm.

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NCT ID: NCT03180996 Not yet recruiting - Clinical trials for Abdominal Aortic Aneurysm

Global Fenestrated Anaconda Clinical sTudy

Global FACT
Start date: July 2017
Phase: N/A
Study type: Observational

This study is a prospective non-interventional, multi-centre study of the Vascutek Fenestrated Anaconda™ system, and is essentially a post-market study. The Vascutek Fenestrated Anaconda™ system is a custom made device used for the treatment of Abdominal Aortic Aneurysm.

NCT ID: NCT03138434 Recruiting - Clinical trials for Abdominal Aortic Aneurysm

Advanced MRI in AAA

Start date: April 12, 2017
Phase: N/A
Study type: Observational

This study aims to determine whether advanced MRI sequences can provide robust and clinically relevant information about abdominal aortic aneurysms (AAAs). The MRI sequences will study outcomes related to blood flow inside AAA, microvasculature of the AAA vessel wall and intraluminal thrombus inside AAA. Robustness of these MRI sequences will be determined with testing of feasibility and reproducibility. Clinical relevance will be assessed by studying the association between the primary outcomes and disease severity. Disease severity will be expressed by AAA diameter. It is our hypothesis that these parameters are significantly related to disease severity and may therefore be future markers of disease progression.

NCT ID: NCT02996396 Recruiting - Clinical trials for Abdominal Aortic Aneurysm

Nellix Registry Study: EVAS-Global

EVAS FORWARD 2
Start date: November 2016
Phase: N/A
Study type: Observational [Patient Registry]

Multicenter, single arm, open label, registry study with consecutive, eligible patient enrollment at each site. All subjects undergoing the Endovascular Aneurysm Sealing System (EVAS) with the Nellix®-System. Subjects will be followed procedurally to discharge, and as per institutional standard of care thereafter through to 5 years (total follow-up commitment)

NCT ID: NCT02973308 Recruiting - Clinical trials for Abdominal Aortic Aneurysm

The Inter and Intra Reliability of Cardiopulmonary Exercise Testing in Abdominal Aortic Aneurysm Patients

CPEX
Start date: September 2016
Phase: N/A
Study type: Interventional

Exercise testing is commonly being used in patients before surgery to test their overall fitness. One group it is being used in is patients who have an enlarged blood vessel in their stomach. This is known as an abdominal aortic aneurysm. The exercise test used is known as a cardiopulmonary exercise test as it looks at both heart and lung function at the same time. Whilst this test is commonly used there have been no studies (to date) which have looked at how reliable this test is; this means how well the investigators can obtain the same (or very similar) results after multiple tests. The investigators would like to test this reliability both between patients and the clinicians performing the testing.

NCT ID: NCT02875444 Completed - Clinical trials for Abdominal Aortic Aneurysm

Measurement of Maximum Diameter of Native Abdominal Aortic Aneurysm by Angio-CT

AAA-angioCT
Start date: January 2013
Phase: N/A
Study type: Observational

Screening for an abdominal aortic aneurysm, monitoring its growth and evaluation of its risk of rupture are based on the measure of its maximum diameter. The abdominal aortic aneurysm's treatment to prevent its rupture is recommended from a threshold of 50-55 mm in men and of 45-50 mm in women. The importance of this measure for patient management justify a specific and homogeneous protocol of measure. However, the diversity of methods of measuring the maximum diameter with scanner and ultrasound was shown. The impact of various angio-CT based measures of maximum AAA diameter, and the impact of reproducibility limits on the decision to operate have never been investigated.

NCT ID: NCT02869464 Recruiting - Clinical trials for Abdominal Aortic Aneurysm

UVA Brain and Aortic Aneurysm Study

BAAS
Start date: April 2014
Phase: N/A
Study type: Observational [Patient Registry]

The purpose of this study is to examine the percentage of patients who present with abdominal aortic aneurysms (AAA) will also have intracranial aneurysms (IA) and conversely; to examine the percentage of patients who present with intracranial aneurysms will also have abdominal aortic aneurysms.

NCT ID: NCT02846883 Recruiting - Clinical trials for Abdominal Aortic Aneurysm

Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms

VIVAAA
Start date: December 5, 2016
Phase: Phase 1
Study type: Interventional

This project is to determine the safety and explore the effectiveness of allogeneic (not cells of the participant but those of another human) mesenchymal stromal cells (MSCs) in decreasing inflammation and possible enlargement of the participants' abdominal aortic aneurysm. Participants will be selected as a possible subject because of an abdominal aortic aneurysm discovered on the ultrasound or computed tomographic ("CT") scan requested by the participants' doctor. The purpose of this study is to collect information that will be used to determine if MSCs can be used to decrease inflammation and possibly slow down enlargement of the participants' aneurysm. The investigators will also be collecting blood samples to study special inflammatory cells that cause aneurysms as well as asking participants to have a "PET" (positron emission tomography) scan that can measure inflammation directly in the participants' aneurysm.

NCT ID: NCT02843854 Not yet recruiting - Clinical trials for Peripheral Artery Disease

Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms

VIVAAA
Start date: October 2016
Phase: Phase 1
Study type: Interventional

This study will assess the safety and efficacy of systemic (IV) administration of escalating doses of allogeneic MSCs in modulating immune cell phenotypes and suppressing aortic inflammation in patients with small AAA. Subjects will be randomized in a 1:1:1 fashion to receive mesenchymal stromal cells (1 million or 3 million MSC/kg) intra-venously or placebo (Plasmalyte A).

NCT ID: NCT02703428 Recruiting - Clinical trials for Abdominal Aortic Aneurysm

TriVascular Evaluation of Females Who Are Underrepresented Candidates for Abdominal Aortic Aneurysm Repair in Europe

LUCY
Start date: July 2016
Phase: N/A
Study type: Observational

The LUCY Study is a prospective, consecutively enrolling, non-randomized multi center post-market study to evaluate the low profile (14F) Ovation® Abdominal Stent Graft Platform when used in the endovascular treatment of female patients.

NCT ID: NCT02689414 Recruiting - Clinical trials for Peripheral Artery Disease

A Study of Remote Ischaemic Preconditioning in Patients With Atherosclerosis Undergoing Vascular Surgery

Start date: January 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effect of preoperative remote ischaemic preconditioning (RIPC) on organ damage and the functional characteristics of arteries in patients undergoing vascular surgery. In addition, we investigate the connection between RIPC and changes in the functional characteristics of arteries and low molecular weight metabolites.