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NCT ID: NCT01487551 Completed - Systemic Sclerosis Clinical Trials

An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis Patients Treated With ABR-215757 (Paquinimod)

Start date: December 2011
Phase: Phase 2
Study type: Interventional

The primary objective is to study changes in disease related biomarkers in patients with progressive SSc during treatment with ABR-215757. The secondary objectives are to assess the safety and tolerability of ABR-215757,to assess disease activity and quality of life (QoL)during treatment with ABR-215757 and to assess the plasma levels of ABR-215757 during the study.

NCT ID: NCT01487213 Completed - Medical Abortion Clinical Trials

Routine Follow-up Versus Self-assessment in Medical Abortion

Start date: September 2011
Phase: N/A
Study type: Interventional

The main objective of the study is to optimize the routines for follow-up after medical abortion in order to give women more autonomy by reducing the number of consultations involved and to reduce the frequency of postabortal curettage. This will be achieved by providing means for women for postabortal self-assessment with the use of a quantitative urinary hCG test.

NCT ID: NCT01486940 Completed - Diabetes Clinical Trials

Comparison of Insulin Detemir Plus Insulin Aspart With Insulin NPH Plus Human Soluble Insulin in Subjects With Type 1 Diabetes

Start date: March 2002
Phase: Phase 3
Study type: Interventional

This trial is conducted in Europe and South America. The aim of this trial is to compare the glycaemic control of insulin detemir plus insulin aspart with that of insulin NPH plus human soluble insulin in subjects with type 1 diabetes on a basal/bolus regimen.

NCT ID: NCT01486927 Completed - Hemophilia A Clinical Trials

An Open-label Safety, Efficacy and Pharmacokinetic Study of a Recombinant FVIII Compared to Recombinant Human Antihemophilic FVIII in Patients With Severe Hemophilia A

Start date: February 2012
Phase: Phase 2/Phase 3
Study type: Interventional

This is an open-label, non-randomized, efficacy, safety and PK study comparing octocog alfa and CSL627. The study consists of three parts, a PK period (Part 1), a continuation of dosing safety and efficacy period (Part 2) and a safety, efficacy, and repeat PK section (Part 3) including a surgical sub-study for subjects enrolled in Parts 2 and 3.

NCT ID: NCT01486875 Completed - Clinical trials for Diabetes Mellitus, Type 2

Observational Study of Safety of NovoMix® 30 Treatment for Type 2 Diabetes

Start
Start date: January 2006
Phase: N/A
Study type: Observational

This trial is conducted in Europe. The aim of this trial is to evaluate the incidence of serious adverse drug reactions when initiating insulin therapy with NovoMix® 30 in subjects with type 2 diabetes mellitus under normal clinical practice conditions in Sweden.

NCT ID: NCT01486641 Completed - Clinical trials for Femoral Neck Fracture

Anterolateral Versus Posterolateral Approach to the Fractured Hip Arthroplasty

APAF
Start date: February 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the anterolateral in comparison to posterolateral approach to the hip arthroplasty gives an equal or better clinical results.

NCT ID: NCT01485991 Completed - Hepatitis C Clinical Trials

TMC435HPC3001 - An Efficacy, Safety and Tolerability Study for TMC435 vs Telaprevir in Combination With PegINFα-2a and Ribavirin in Chronic Hepatitis C Patients Who Were Null or Partial Responders to Prior PegINFα-2a and Ribavirin Therapy

ATTAIN
Start date: February 2012
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate the efficacy of TMC435 in combination with peginterferon (PegIFN) + ribavirin (RBV) by means of establishing its non- inferiority compared to an approved regimen of telaprevir + PegIFN + RBV in patients who have previously failed PegIFN.

NCT ID: NCT01485315 Completed - Septic Shock Clinical Trials

Transfusion-requirements in Septic Shock Trial

TRISS
Start date: November 2011
Phase: Phase 3
Study type: Interventional

Patients with blood poisoning - sepsis - often receive blood transfusions in the intensive care unit. The evidence that blood transfusion leads to improved outcome is limited and the blood may be harmful to some of these patients. To bridge the gap between clinical practice and evidence, a large randomised clinical trial is needed to document the efficacy and safety of RBC transfusion in these very sick patients

NCT ID: NCT01485302 Completed - Alzheimer's Disease Clinical Trials

Single and Repeated Dosing Study to Assess the Safety and the Concentration-time Profile of SAR228810 in Alzheimer's Patients

Start date: January 2012
Phase: Phase 1
Study type: Interventional

Primary Objective: - To assess the safety and tolerability of escalating single and multiple doses of SAR228810 in patients with Alzheimer's disease (AD) Secondary Objective: - To evaluate the pharmacokinetic properties of SAR228810 after escalating single and multiple doses of SAR228810 in AD patients

NCT ID: NCT01485159 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Airflow Limitation in Cardiac Diseases in Europe

ALICE
Start date: October 2011
Phase: N/A
Study type: Observational

This is a cross-sectional, observational study, investigating the point prevalence of Airflow Limitation in current or former smokers with established ischemic heart disease. The study will recruit up to 3000 patients from cardiology clinics at hospitals across Europe.