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NCT ID: NCT00430716 Terminated - Clinical trials for Pulmonary Arterial Hypertension

To Assess The Efficacy and Safety Of Oral Sildenafil in the Treatment of Pulmonary Arterial Hypertension.

Start date: April 8, 2008
Phase: Phase 4
Study type: Interventional

To demonstrate a dose response for 1 mg, 5 mg and 20 mg TID oral sildenafil for the treatment of subjects with PAH.

NCT ID: NCT00430352 Completed - Clinical trials for Non-Hodgkin's Lymphoma

MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma.

Start date: September 2006
Phase: Phase 4
Study type: Interventional

This single arm study will evaluate the safety and efficacy of MabThera maintenance therapy following a MabThera-containing induction regimen in first line or relapsed patients with follicular non-Hodgkin's lymphoma. All patients will receive MabThera 375mg/m2 body surface area, as an intravenous infusion, every 8 weeks. The anticipated time on study treatment is 1-2 years, and the target sample size is 500+ individuals.

NCT ID: NCT00428948 Completed - Clinical trials for Polycystic Kidney Disease, Autosomal Dominant

Tolvaptan Phase 3 Efficacy and Safety Study in ADPKD

TEMPO3/4
Start date: January 2007
Phase: Phase 3
Study type: Interventional

This study's purpose is to evaluate the long-term safety and efficacy of tolvaptan versus placebo in patients with ADPKD.

NCT ID: NCT00426660 Completed - Clinical trials for Advanced HIV Infection

Expanded Access Program for Maraviroc At Multiple Centers

Start date: February 2007
Phase: Phase 3
Study type: Interventional

To provide access to maraviroc to patients who have limited or no therapeutic treatment options and to collect more safety data in a broader patient population.

NCT ID: NCT00425919 Terminated - Diabetes Mellitus Clinical Trials

Study Evaluating PPM-204 In Subjects With Type 2 Diabetes

Start date: January 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to learn whether PPM-204 has an effect on lowering blood glucose (blood sugar) levels and is safe in treating people with type 2 diabetes.

NCT ID: NCT00424476 Completed - Clinical trials for Systemic Lupus Erythematosus

A Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)

BLISS-52
Start date: May 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy, safety, tolerability, and impact on quality of life of two different doses of belimumab administered in addition to standard therapy in subjects with active, autoantibody-positive systemic lupus erythematosus (SLE) disease.

NCT ID: NCT00424190 Completed - Clinical trials for Bacterial Infections

Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections

cSSSI
Start date: February 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.

NCT ID: NCT00423501 Completed - Clinical trials for Diabetes Mellitus Type 2

A Study of a GLP-1 Analogue in Patients With Type 2 Diabetes Treated With Metformin.

Start date: February 2007
Phase: Phase 2
Study type: Interventional

This 6 arm study will evaluate the efficacy, safety, pharmacokinetics and pharmacodynamics of multiple doses and regimens of a GLP-1 analogue in patients with type 2 diabetes who are treated with a stable dose of metformin. Patients will be randomized to receive either subcutaneous placebo, or subcutaneous GLP-1 analogue, 5mg, 10mg or 20mg weekly, or 10mg or 20mg every 2 weeks. All patients will continue on their existing metformin treatment regimen throughout the study. The anticipated time on study treatment is <3 months, and the target sample size is 100-500 individuals.

NCT ID: NCT00423319 Completed - Pulmonary Embolism Clinical Trials

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3)

Start date: March 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn whether apixaban can prevent the blood clots in the leg (deep vein thrombosis) and lung (pulmonary embolism) that sometimes occur after hip replacement surgery and to learn how apixaban compares with enoxaparin in preventing these clots. The safety of apixaban will also be studied

NCT ID: NCT00421109 Completed - Urticaria Clinical Trials

Efficacy Study for the Symptomatic Treatment of Chronic Idiopathic Urticaria

Start date: July 2006
Phase: Phase 3
Study type: Interventional

The objective of the study is to evaluate the efficacy and tolerability of Bilastine 20 mg Q.D., compared to Levocetirizine 5 mg Q.D. and placebo for the treatment of Chronic Idiopathic Urticaria.