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NCT ID: NCT00458393 Completed - HIV Infections Clinical Trials

Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men

iPrEx
Start date: June 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether daily use of emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) can prevent HIV infection in men who also receive HIV counseling, condoms, and treatment for other sexually transmitted infections (STIs).

NCT ID: NCT00457002 Completed - Pulmonary Embolism Clinical Trials

Study of Apixaban for the Prevention of Thrombosis-related Events in Patients With Acute Medical Illness

ADOPT
Start date: June 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn if apixaban can prevent blood clots in the leg (deep vein thrombosis [DVT]) and lung (pulmonary embolism [PE]) that sometimes occur within patients hospitalized for acute medical illness, and to learn how apixaban compares to enoxaparin (Lovenox®) for preventing these clots. The safety of apixaban will also be studied.

NCT ID: NCT00455533 Completed - Breast Cancer Clinical Trials

Study to Assess Effectiveness of Giving Combination of Standard Chemotherapy Drugs Versus Combination of Standard Chemotherapy and New Drug Ixabepilone When Given Before Surgical Removal of Early Stage Breast Cancer

Start date: October 2007
Phase: Phase 2
Study type: Interventional

The study will evaluate the effectiveness of ixabepilone when given after doxorubicin plus cyclophosphamide (AC) compared to standard treatment of paclitaxel given after doxorubicin plus cyclophosphamide in patients with early stage breast cancer. In addition the study will verify predefined biomarkers as well as discover new biomarkers that could identify patients who are more likely to respond to ixabepilone than standard paclitaxel based therapy.

NCT ID: NCT00454389 Active, not recruiting - Clinical trials for Macular Degeneration

A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration

CABERNET
Start date: April 2007
Phase: Phase 3
Study type: Interventional

The objective of the CABERNET Trial is to evaluate the safety and efficacy of focal delivery of radiation for the treatment of subfoveal choroidal neovascularization (CNV) associated with wet age-related macular degeneration (AMD). The Epi-Rad90™ Ophthalmic System treats neovascularization of retinal tissue by means of a focal, directional delivery of radiation to the target tissues in the retina. Using standard vitreoretinal surgical techniques, the sealed radiation source is placed temporarily over the retinal lesion by means of a handheld medical device.

NCT ID: NCT00449982 Completed - Clinical trials for Condylomata Acuminata

Efficacy and Safety Study of Polyphenon E to Treat External Genital Warts

Start date: July 2003
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the clinical efficacy, safety and tolerability of a Polyphenon E Ointment 10% and a Polyphenon E Ointment 15% in the treatment of external genitial warts in male and female patients.

NCT ID: NCT00449644 Completed - Tuberculosis Clinical Trials

TMC207-TiDP13-C208: Anti-bacterial Activity, Safety, and Tolerability of TMC207 in Participants With Multi-drug Resistant Mycobacterium Tuberculosis (MDR-TB).

Start date: June 2007
Phase: Phase 2
Study type: Interventional

The objective of this study is to demonstrate that the antibacterial activity of TMC207 is better than placebo when added to a standardized Background Regimen (BR) for treatment of multi-drug resistant TB. Also safety and tolerability will be evaluated.

NCT ID: NCT00446797 Completed - Ankle Sprain Clinical Trials

Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain

Start date: May 2007
Phase: Phase 4
Study type: Interventional

To assess the efficacy of celecoxib loading dose of 400mg followed by 200 mg twice a day (BID) versus oral non-selective NSAIDs in acute pain due to ankle sprain.

NCT ID: NCT00444925 Completed - Overactive Bladder Clinical Trials

Clinical Trial to Evaluate the Efficacy and Safety of Fesoterodine in Comparison to Tolterodine for Overactive Bladder (OAB)

Start date: April 2007
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy and safety of fesoterodine in comparison to tolterodine and placebo for overactive bladder

NCT ID: NCT00443118 Completed - Resuscitation Clinical Trials

Newborn Ventilation in the Delivery Room: Could it be Improved With a T-piece Resuscitator?

Start date: December 2009
Phase: Phase 3
Study type: Interventional

A multicenter cross-over cluster randomized controlled trial protocol study in newborn infants ≥ 26 weeks gestational age requiring assisted ventilation (positive pressure ventilation [PPV]) for resuscitation in the delivery room comparing a T-piece resuscitator device versus resuscitation bag.

NCT ID: NCT00442962 Completed - HIV Infections Clinical Trials

HIV Treatment Reinitiation in Women Who Received Anti-HIV Drugs to Prevent Mother-to-Child Transmission of HIV

Nearly Naive
Start date: May 2007
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if pregnancy-limited, short-term combination HIV treatment regimens -- which were used solely for the prevention of mother to child transmission of HIV and discontinued postpartum -- decreases the effectiveness of a standard initial regimen of anti-HIV drugs when subsequent treatment is needed.