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NCT ID: NCT00148252 Terminated - Clinical trials for Renal Transplantation

Lowering Total Immunosuppressive Load in Renal Transplant Recipients More Than 12 Months Posttransplant

Start date: February 2003
Phase: Phase 4
Study type: Interventional

To compare the change in renal function between CsA or MMF withdrawal from before to 12 months after drug withdrawal in renal transplant recipients on triple immunosuppressive therapy

NCT ID: NCT00147784 Completed - Opiate Dependence Clinical Trials

HEPMET-1: Evaluate the Feasibility, Mental Sideeffects and the Efficacy of Hepatitis C Treatment in a MMT Group.

Start date: March 2006
Phase: Phase 3
Study type: Interventional

- To evaluate if weekly psychological follow-up make opioid dependent patients in MMT able to accomplish 14 weeks treatment with Peginterferon alfa-2a (PEG-INF) and ribavirin to the same extent than non-opioid dependents. - To determine the efficacy of this anti-HCV treatment

NCT ID: NCT00145691 Completed - Clinical trials for Agitation Aggression in Dementia

The Effect of Oxcarbazepine in the Treatment of Agitation / Aggression in Dementia (OBAD)

Start date: September 2005
Phase: Phase 3
Study type: Interventional

We intend to conduct a phase III b trial to verify Oxcarbazepine's effect in agitation and aggression in patients with dementia. We designed the study as a randomized, double-blind, placebo-controlled multi center trial. Hundred patients will be included. The treatment period will be eight weeks, with a further follow up of four weeks. The primary outcome measure will be the reduction in aggression and agitation as measured by means of NPI-NH-subscale agitation / aggression (Neuropsychiatric Inventory, Nursing Home Version). Secondary outcomes are reduction in aggression as measured by BARS (Behavior Agitation Rating Scale)and reduction in the burden to health-care personnel as measured by NPI-NH.

NCT ID: NCT00145574 Completed - Clinical trials for Hypercholesterolemia

Efficacy and Safety of Colesevelam in Pediatric Patients With Genetic High Cholesterol

Start date: November 2005
Phase: Phase 4
Study type: Interventional

This study will evaluate the lipid-lowering effect and safety of colesevelam therapy administered to heterozygous familial pediatric patients 10 through 17 years of age who are on a stable dose of a pediatric-approved statin monotherapy (atorvastatin, lovastatin, simvastatin or pravastatin), or who are treatment naive to lipid-lowering therapy.

NCT ID: NCT00145314 Completed - Clinical trials for Metastatic Colorectal Cancer

FLOX in Combination With Cetuximab in First-line Treatment of Colorectal Cancer

Start date: May 2005
Phase: Phase 3
Study type: Interventional

The main objective of this trial is to explore the effect of combining an established chemotherapy regimen (FLOX), based on 5-fluorouracil, folinic acid, and oxaliplatin (Eloxatin®), with the EGF receptor antibody cetuximab (Erbitux®) in first-line treatment of metastatic colorectal cancer. The trial will investigate two regimens of FLOX plus cetuximab, in which FLOX is given continuously or intermittently, compared to standard FLOX without cetuximab.

NCT ID: NCT00144339 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients

Start date: December 2002
Phase: Phase 3
Study type: Interventional

The primary objective of this trial is to determine whether daily treatment with tiotropium (Spiriva®, Bromuro de Tiotropio®) inhalation capsule via HandiHaler® reduces the rate of decline in lung function over time in patients with COPD.

NCT ID: NCT00143286 Completed - Smoking Cessation Clinical Trials

A 52-Week Multicenter Study Evaluating the Safety and Efficacy of Varenicline for the Maintenance of Smoking Cessation

Start date: April 2003
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is a comparison of abstinence maintenance in subjects randomized to double-blind varenicline or placebo from Weeks 13 -24 in subjects who responded to an intial 12-week open label course of varenicline, with post-treatment follow-up of smoking status to Week 52.

NCT ID: NCT00141518 Completed - Clinical trials for Advanced Idiopathic Parkinson's Disease

DAPHNE (Duodopa in Advanced Parkinson's: Health Outcomes & Net Economic Impact)

Start date: January 2006
Phase: Phase 4
Study type: Interventional

Health economics long-term study

NCT ID: NCT00141323 Completed - Osteoporosis Clinical Trials

Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL)

PEARL
Start date: November 2001
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine the safety and effectiveness of 2 doses of the investigational drug, lasofoxifene, compared to placebo (an inactive substance) in reducing new spinal fractures in women with osteoporosis.

NCT ID: NCT00141193 Completed - Colorectal Adenoma Clinical Trials

Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP)

PRESAP
Start date: February 2001
Phase: Phase 3
Study type: Interventional

This study is a prospective, randomized, double-blind, placebo-controlled, multi-center trial to compare the efficacy and safety of celecoxib 400mg QD versus placebo in reducing the occurrence of new colorectal adenomas post-polypectomy at Month 13 (Year 1) and Month 37 (Year 3) of study drug administration.