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NCT ID: NCT00603525 Terminated - Clinical trials for Arthritis, Rheumatoid

Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to TNF-α Antagonist Therapy

Start date: January 2008
Phase: Phase 3
Study type: Interventional

This is a phase III, double-blind, randomized, multicenter, and parallel group trial with a duration of 24 weeks, followed by a 120 week Open-label Period. The primary purpose of the study is to demonstrate the efficacy and safety of ofatumumab in reducing clinical signs and symptoms in adult RA patients who had an inadequate response to TNF-α antagonist therapy.

NCT ID: NCT00602511 Completed - Multiple Myeloma Clinical Trials

Thalidomide Versus Bortezomib in Melphalan Refractory Myeloma

Start date: October 2007
Phase: Phase 3
Study type: Interventional

The purpose of the study is to compare thalidomide + dexamethasone with bortezomib + dexamethasone in patients with multiple myeloma refractory to melphalan therapy. The main goal is to find out which of these two 2:nd line regimens that offers the patients the best chance for a response with as long duration and as good quality of life as possible.

NCT ID: NCT00600886 Active, not recruiting - Acromegaly Clinical Trials

Safety and Efficacy of Pasireotide Long Acting Release (LAR) vs. Octreotide LAR in Patients With Active Acromegaly

Start date: February 2008
Phase: Phase 3
Study type: Interventional

The patients will receive either Pasireotide LAR or Octreotide LAR for one year of treatment. The objective of this study is to compare the proportion of patients with a reduction of mean GH level to <2.5 µg/L and the normalization of IGF-1 to within normal limits (age and sex related) between the two treatment groups (pasireotide LAR and octreotide LAR) at 12 months. Following one year of treatment patients may proceed into the study extension. Patients who did not respond to the treatment they were randomized to (based on month 12 assessment results) will be switched to the other treatment arm at month 13.

NCT ID: NCT00599911 Completed - Clinical trials for Major Depressive Disorder

Dose-finding Study With Lu AA24530 in Major Depressive Disorder

Start date: October 2007
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to assess the efficacy in treating patients with Major Depressive Disorder of one or more doses of Lu AA24530 relative to placebo

NCT ID: NCT00599196 Completed - Clinical trials for Early Stage Parkinson's Disease

An Open-Label Extension Trial to Assess the Safety of Long-Term Treatment of Rotigotine in Early-Stage Parkinson's Disease

Start date: August 2002
Phase: Phase 3
Study type: Interventional

The objective of this open-label extension is to assess the safety and tolerability of long-term treatment of the rotigotine patch in subjects with early-stage idiopathic Parkinson's disease

NCT ID: NCT00598845 Recruiting - Neoplasm Metastasis Clinical Trials

Molecular Markers in Treatment in Endometrial Cancer

MoMaTEC
Start date: April 2001
Phase: N/A
Study type: Observational

The purpose of this prospective multicenter trial is to investigate the value of molecular markers in endometrial cancer for predicting lymph node metastasis and prognosis in relation to treatment.

NCT ID: NCT00594607 Completed - Clinical trials for Extracorporeal Clotting During Hemodialysis

Effect of Nephral 400 ST Dialysis Membrane on Coagulation in Hemodialysis

Start date: September 2004
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether the dialysis filter AN69ST (Nephral 400 ST Dialysis Membrane) induces less clotting during hemodialysis than a conventional polysulphone filter. Our hypothesis is that the two filters induce the same degree of clotting.

NCT ID: NCT00594269 Completed - Dementia Clinical Trials

Dementia Antipsychotics And Antidepressants Discontinuation Study

DESEP
Start date: August 2008
Phase: Phase 4
Study type: Interventional

The aim of this study is to discontinue antipsychotics and antidepressants, and to study its effect on Behavioural- and Psychological Symptoms in Dementia (BPSD).

NCT ID: NCT00592397 Completed - Obesity Clinical Trials

Prestudy: Lifestyle and Cardiovascular Disease

Start date: March 2006
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to optimize conditions for a planned human intervention study focusing on how diet predispose for, and influence, lifestyle disease development and its consequence in cardiovascular disease development.

NCT ID: NCT00592098 Completed - Pain Clinical Trials

2PX (Topical Strontium Chloride Hexahydrate) in Patients With Post-Amputation Stump Pain.

Start date: August 2007
Phase: Phase 2
Study type: Interventional

The objective of this study is to investigate the analgesic effect of topical strontium chloride in stump pain, and to prospectively determine other efficacy and safety measures of topical strontium chloride in stump pain.