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NCT ID: NCT02478008 Recruiting - Clinical trials for Cardiovascular Disease

A Clinical Study of the CardiAQ™ TMVI System (Transapical DS)

Start date: June 2015
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the initial short and long-term safety and performance of the CardiAQ™ Transcatheter Mitral Valve Implantation System using the Transapical Delivery System. The study will enroll patients with moderate to severe mitral valve regurgitation who are considered high or extreme risk for mortality and morbidity from conventional open heart surgery.

NCT ID: NCT02477826 Active, not recruiting - Clinical trials for Non-Small Cell Lung Cancer

An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)

CheckMate 227
Start date: August 5, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to show that Nivolumab, or Nivolumab plus Ipilimumab, or Nivolumab plus Platinum-Doublet Chemotherapy improves progression free survival and/or overall survival compared with chemotherapy in patients with advanced lung cancer.

NCT ID: NCT02477696 Active, not recruiting - Clinical trials for Chronic Lymphocytic Leukemia

Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

Start date: July 28, 2015
Phase: Phase 3
Study type: Interventional

This study is designed to evaluate progression-free survival (PFS) endpoint for acalabrutinib versus (vs) ibrutinib in previously treated chronic lymphocytic leukemia.

NCT ID: NCT02477618 Completed - Clinical trials for Super-Refractory Status Epilepticus

A Study With SAGE-547 for Super-Refractory Status Epilepticus

Start date: June 2015
Phase: Phase 3
Study type: Interventional

This is a randomized, double-blind, placebo-controlled trial, designed to evaluate the efficacy and safety of SAGE-547 administered as a continuous intravenous infusion to subjects in Super-Refractory Status Epilepticus (SRSE).

NCT ID: NCT02477397 Active, not recruiting - COPD Clinical Trials

Symptom-driven Maintenance and Reliever Treatment to Prevent Exacerbations in COPD

Start date: May 1, 2015
Phase: Phase 3
Study type: Interventional

Study to investigate the effects of symptom-driven maintenance and reliever therapy in COPD.

NCT ID: NCT02477241 Not yet recruiting - Clinical trials for Urinary Bladder, Overactive

Brain Areas Involved in Bladder Filling and Contraction

Start date: September 2015
Phase: N/A
Study type: Interventional

Overactive Bladder syndrome (OAB) is a medical condition with symptoms of urgency, with or without incontinence, usually with frequency and nocturia, with no proven infection or obvious pathology 1. This study will explore the relationship between OAB, obstruction and the micro contractions as well as the brain areas involved in both normal desire to void and urgency, gaining a better understanding of the bladder pathophysiology and in the future allowing better strategy of treatment options for patients suffering from OAB.

NCT ID: NCT02477111 Completed - Clinical trials for Abdominal Aortic Aneurysms

European (EU) Post Approval Study of the INCRAFT® AAA Stent Graft System in Subjects With Abdominal Aortic Aneurysms

INSIGHT
Start date: March 30, 2015
Phase:
Study type: Observational

INSIGHT is a postmarket clinical follow-up study in the European Union. The purpose of the study is to continue to evaluate the safety and effectiveness/performance of INCRAFT in subjects with abdominal aortic aneurysms requiring endovascular repair in routine clinical practice. Approximately 150 subjects will be enrolled and followed through 5-years post procedure. Up to 25 sites in Europe may participate.

NCT ID: NCT02476916 Active, not recruiting - Clinical trials for Pyruvate Kinase Deficiency

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

Start date: June 26, 2015
Phase: Phase 2
Study type: Interventional

Study AG348-C-003 is a multicenter study designed to evaluate the safety and efficacy of different dose levels of AG-348 (mitapivat) in participants with PK deficiency.

NCT ID: NCT02476552 Completed - Cancer Clinical Trials

Absorption, Metabolism, Excretion, and the Determination of Absolute Bioavailability of Niraparib in Subjects With Cancer

Start date: February 2015
Phase: Phase 1
Study type: Interventional

This is an open-label study with 2 parts, plus an extension study following completion of Parts 1 or 2, that is being conducted in approximately 12 subjects (6 subjects in Part 1; 6 subjects in Part 2) with cancer to examine the absorption, metabolism, excretion, and absolute bioavailability of niraparib.

NCT ID: NCT02476058 Completed - Clinical trials for Major Depressive Disorder

A Safety, Efficacy and Biomarker Study of JNJ-42847922 in Participants With Major Depressive Disorder

Start date: June 11, 2015
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability of JNJ-42847922 in participants with Major Depressive Disorder (MDD).