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Abdominal Aortic Aneurysms clinical trials

View clinical trials related to Abdominal Aortic Aneurysms.

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NCT ID: NCT03469245 Recruiting - Clinical trials for Abdominal Aortic Aneurysms

Validation of Fenestrations Positioning by Numerical Simulation

FenSim
Start date: June 15, 2018
Phase:
Study type: Observational

Fenestrated endovascular repair (FEVAR) is nowadays a recognized option to treat juxtarenal, pararenal or suprarenal abdominal aortic aneurysms in patients at high risk for conventional repair. The technique consists in deploying a custom-made stent-graft (SG) inside the patient aorta. Part of the customization involves cauterizing a hole in SG fabric and reinforcing it with a Nitinol stent ring, thereby creating a fenestration for each corresponding collateral artery. For this reason, preoperative planning is crucial to determine adequate positions of fenestrations, in order to obtain perfect alignment with the collateral arteries of the patient. Inadequate positioning may result in failure to catheterize a collateral artery and subsequent organ damage, increased catheterizing time, increased irradiation dose, endoleaks… The current process of fenestrations positioning for fenestrated anacondaTM SG involves: (i) anatomical measurements on patient preoperative CT-scan by case planners using dedicated sizing software; (ii) designing an initial custom device scheme with its positioned fenestrations, created by engineers with CAD software using the above cited measurements and (iii) validation of fenestrations position by in vitro testing using a SG prototype deployed inside a transparent anatomy model (3D-printed model of patient aorta and collateral arteries). The main limitations of this process are the costs and long SG delivery time.

NCT ID: NCT02888613 Not yet recruiting - Clinical trials for Abdominal Aortic Aneurysms

Mini-laparotomy Versus Mini Lumbotomy

RAMini
Start date: September 2018
Phase: N/A
Study type: Interventional

This study aims to compare the results of two mini invasive surgical approaches in abdominal aortic surgery: mini lumbotomy with retroperitoneal approach versus mini laparotomy with transperitoneal approach. Respiratory and renal functions and recovery of intestinal transit will be assessed after 30 days. The secondary purpose of this study is to assess the life quality and morbi-mortality at 30 days, as well as at 6 and 12 months.

NCT ID: NCT02577562 Approved for marketing - Clinical trials for Abdominal Aortic Aneurysms

Zenith® Fenestrated Abdominal Aortic Aneurysm (AAA) Endovascular Graft Continued Access Study

Start date: n/a
Phase: N/A
Study type: Expanded Access

The Zenith®Fenestrated AAA Endovascular Graft Clinical Study is a clinical investigation approved by the US FDA to study the safety and effectiveness of the Zenith® Fenestrated AAA Endovascular Graft in the treatment of abdominal aortic and aorto-iliac aneurysms.

NCT ID: NCT02557659 No longer available - Clinical trials for Abdominal Aortic Aneurysms

Zenith® Low Profile AAA Endovascular Graft

Start date: n/a
Phase: N/A
Study type: Expanded Access

This extended investigation is to provide continued physician access to the device and collect confirmatory safety and effectiveness data.

NCT ID: NCT02535065 Active, not recruiting - Clinical trials for Abdominal Aortic Aneurysms

Zenith® Low Profile AAA Endovascular Graft

Start date: August 2014
Phase: N/A
Study type: Interventional

The Zenith® Low Profile AAA Endovascular Graft Clinical Study is a clinical trial to study the safety and effectiveness of the Zenith® Low Profile AAA Endovascular Graft used in conjunction with the Zenith® Spiral-Z® AAA Iliac Leg Graft to treat abdominal aortic, aortoiliac, and iliac aneurysms.

NCT ID: NCT02480595 Recruiting - Clinical trials for Abdominal Aortic Aneurysms

AAA Registry: Clinical Outcomes of Highly Angulated anatomY Treated With the Aorfix™ Stent Graft

ARCHYTAS
Start date: April 2015
Phase: Phase 4
Study type: Observational [Patient Registry]

The ARCHYTAS Registry is a long-term, global, multicenter, non-randomized, prospective, registry designed to collect "on-label" data in real world clinical settings on patients undergoing endovascular repair with the latest generation Aorfix™ AAA Flexible Stent Graft System. Registry data will augment existing data from ongoing and prospective Aorfix™ clinical trials for the purposes of publication, general product development and quality measures.

NCT ID: NCT02477111 Active, not recruiting - Clinical trials for Abdominal Aortic Aneurysms

European (EU) Post Approval Study of the INCRAFT® AAA Stent Graft System in Subjects With Abdominal Aortic Aneurysms

INSIGHT
Start date: March 2015
Phase: N/A
Study type: Observational

INSIGHT is a postmarket clinical follow-up study in the European Union. The purpose of the study is to continue to evaluate the safety and effectiveness/performance of Incraft in subjects with abdominal aortic aneurysms requiring endovascular repair in routine clinical practice. Approximately 150 subjects will be enrolled and followed through 5-years postprocedure. Up to 25 sites in Europe may participate.

NCT ID: NCT02345005 Active, not recruiting - Aneurysm Clinical Trials

Iliac Branch Excluder ReGistry (IceBERG)

IceBERG
Start date: November 2014
Phase:
Study type: Observational [Patient Registry]

This post market registry consists of a retrospective and a prospective part. The first part is a retrospective registry of all implanted IBE devices of Gore in the Netherlands after CE mark was obtained, to get an initial insight on the feasibility and safety of this procedure. The second part is to prospectively register all data on implanted IBE Gore devices, in order to gain more robust data on the efficacy of the device in maintaining hypogastric artery patency.

NCT ID: NCT02125890 Recruiting - Clinical trials for Abdominal Aortic Aneurysms

Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms

TARAA
Start date: July 2014
Phase: Phase 3
Study type: Interventional

An abdominal aortic aneurysm occurs when the part of the aorta travelling down into the abdomen balloons out more than 50%. If caught early, treatments can be used to prevent rupture of the aneurysm. However, many of these aneurysms are asymptomatic and go undetected until they rupture, causing large amounts of blood to spill into the abdominal cavity and typically leads to death, if left untreated. The current mortality rate is between 50 and 90%. The resources required to treat patients with ruptured aortic aneurysms is quite substantial given that they need blood transfusions and can have prolonged hospital stays. Patients either undergo a more invasive operative repair, associated with greater blood products transfusions and complications, or if relatively stable, undergo a less invasive repair with tubes called stents. There is less morbidity associated with the latter, endovascular repair. To prevent blood loss in elective surgeries, drugs that promote blood clotting are often used. One drug, tranexamic acid , has been shown to reduce blood loss, reduce the number of blood transfusions required and improve patient outcomes in elective cardiac and orthopaedic surgeries, and more recently, in patients with traumatic hemorrhage. However, this drug has not been tested in this particular population. The purpose of this pilot project is to evaluate the effectiveness of tranexamic acid in reducing clinically significant bleeding in patients with ruptured aortic aneurysms in hospital sites across Saskatchewan using a single-group intervention design. The investigators will compare the data from patients treated with tranexamic acid to retrospective data from a control group that is matched on key variables. The investigators predict that tranexamic acid will result in reduced bleeding, reduced need for blood transfusions, less patients that require open surgery and improved patient outcomes. The results of this study will help determine if this treatment is effective at preventing the death of many people with ruptured abdominal aortic aneurysms.

NCT ID: NCT02048514 Active, not recruiting - Clinical trials for Abdominal Aortic Aneurysms

The Nellix® EndoVascular Aneurysm Sealing System for the Treatment of Infrarenal Abdominal Aortic Aneurysms

Start date: December 2008
Phase: N/A
Study type: Interventional

The purpose of this clinical study is to evaluate the safety and device performance of the Nellix® EndoVascular Aneurysm Sealing System (Nellix System) for the treatment of infrarenal abdominal aortic aneurysms.