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NCT ID: NCT00527683 Completed - Cocaine Dependence Clinical Trials

Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence

Start date: April 2007
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to assess the efficacy of vigabatrin for the treatment of cocaine dependence, based on the twice-weekly qualitative urine toxicologies for cocaine. Based on two prior unblinded human studies and 15 years of animal studies, this 100 subject double- blind, randomized study is designed to show if with vigabatrin treatment but not placebo, even non-hospitalized cocaine dependent individuals with ready access to cocaine will become cocaine abstinent if they are self motivated to stop their cocaine habit. To accomplish this, cocaine dependent subjects will be randomly assigned to either a placebo or vigabatrin treatment group and treated for a nine week period. The primary hypothesis is that as compared to the placebo arm, the vigabatrin treatment arm will show a significant increase in the number of subjects who are abstinent for the final 3 weeks of the study.

NCT ID: NCT00526669 Completed - Clinical trials for Neoplasms, Gastrointestinal Tract

Study For Patients With Untreated Gastric Cancer Who Will Receive Capecitabine And Lapatinib

Start date: March 2008
Phase: Phase 2
Study type: Interventional

The study will determine if changes in expression of markers involved in the 5-FU pathways are associated with response to treatment with the combination of lapatinib and capecitabine independent of tumor erbB2 status.

NCT ID: NCT00522873 Completed - Postmenopause Clinical Trials

Endometrial Safety Study

Start date: August 2007
Phase: Phase 3
Study type: Interventional

The study is designed to investigate the safety of the investigational product for the lining of the uterus (endometrium).

NCT ID: NCT00522704 Recruiting - Clinical trials for Arteriovenous Fistula

Correlation Between Access Blood Flow and Extracorporeal Blood Flow

Start date: March 2008
Phase: N/A
Study type: Observational

The purpose of this study is to determine if Effective Extracorporeal Blood Flow(eEBF) has correlation with Access Blood Flow (Qa), when eEBF adjusts with Dynamic Arterial Line Pressure (DALP) in patients with Arteriovenous fistulae in hemodialysis treatment.

NCT ID: NCT00522379 Completed - Parkinson's Disease Clinical Trials

Trial to Assess Parkinson's Disease (PD) Symptom Control to Four Doses of Rotigotine in a Transdermal Patch

Start date: July 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to show Rotigotine dose response at four doses of Rotigotine used with L-dopa in treating advanced stage Parkinson's disease.

NCT ID: NCT00521365 Completed - Bipolar Disorder Clinical Trials

Effectiveness of Quetiapine XR on the Control of Symptoms of Manic Phase of Bipolar Disorder.

EMMY
Start date: May 2008
Phase: Phase 4
Study type: Interventional

The primary purpose of the study is to assess the efficacy of Quetiapine extended release 600mg per day either as monotherapy or combined therapy in the treatment of patients with mania associated to Bipolar disorder. This trial will also assess the life quality and productivity loss improvement for patients from baseline to day 21.

NCT ID: NCT00520923 Completed - Schizophrenia Clinical Trials

A Study for Patients With Schizophrenia

Start date: September 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test the hypothesis that 1 or more dose levels of LY2140023 given orally to patients with schizophrenia twice daily for 4 weeks will have significantly greater effect than placebo.

NCT ID: NCT00520676 Completed - Clinical trials for Non-Small Cell Lung Cancer

Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer

Start date: October 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the combination of pemetrexed and carboplatin with the combination of docetaxel and carboplatin in terms of survival without Grade 3 or 4 toxicity in previously untreated patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).

NCT ID: NCT00520572 Completed - Clinical trials for Rheumatoid Arthritis

A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA)

Start date: August 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to confirm that AZD9056 is effective in treating rheumatoid arthritis with regard to signs and symptoms and to determine what dose is favourable over a 6-month treatment period. Patients will receive background treatment with either Methotrexate or Sulphasalazine

NCT ID: NCT00518154 Completed - HIV Infections Clinical Trials

Pilot Study of Pyridostigmine Upon Immune Activation in HIV-1 Patients Who Have an Inadequate Immune Response

Start date: September 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether the addition of Pyridostigmine to Highly Active Antiretroviral Therapy (HAART) increases the number of CD4+ T-cells in discordant patients in which viral load diminishes, but T-cell levels remain low after the initiation of treatment.