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NCT ID: NCT00665925 Completed - Clinical trials for Rheumatoid Arthritis

Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis

Taski-2
Start date: May 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether the Spleen Tyrosine Kinase (Syk) inhibitor, R935788 (R788), at a dose of 100 mg, orally, twice-a-day, and/or a dose of of 150 mg, orally, once-a-day is effective in the treatment of Rheumatoid Arthrits in patients who have had an inadequate clinical response to methotrexate.

NCT ID: NCT00664716 Completed - Clinical trials for Rheumatoid Arthritis

Assessment Of The Safety And Efficacy Of BG9924 In Rheumatoid Arthritis (RA) Participants

RESPOND
Start date: July 2007
Phase: Phase 2
Study type: Interventional

Safety and efficacy of BG9924 in RA participants that have had an inadequate response to disease-modifying anti-rheumatic drug (DMARD) therapy.

NCT ID: NCT00664573 Terminated - Clinical trials for Rheumatoid Arthritis

104RA204 Assessment of the Safety and Efficacy of BG9924 in Rheumatoid Arthritis (RA) Participants

RESPOND-EXT
Start date: November 2007
Phase: Phase 2
Study type: Interventional

To observe the long-term treatment with BG9924 when administered to participants with RA who previously participated in a Biogen Idec Study.

NCT ID: NCT00664534 Completed - Clinical trials for Diabetes Mellitus, Type 2

Pre-Mix Insulin Lispro Treatment for Type 2 Diabetes Patients Who Consume a Light Breakfast

Start date: April 2008
Phase: Phase 4
Study type: Interventional

This study is designed to look at how best to start and then gradually intensify (as needed) the insulin lispro premix regimen in type 2 diabetes patients who consume a light breakfast.

NCT ID: NCT00663702 Completed - Clinical trials for Arthritis, Rheumatoid

Phase IIIB Switching From Intravenous to Subcutaneous Study

Start date: May 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether switching to subcutaneous administration of abatacept will be safe in participants with rheumatoid arthritis who previously received long-term therapy with intravenous abatacept

NCT ID: NCT00663260 Completed - Clinical trials for Diabetes Mellitus, Type 2

Glycemic Efficacy and Renal Safety Study of Dapagliflozin in Subjects With Type 2 Diabetes Mellitus and Moderate Renal Impairment

Start date: June 2008
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine whether dapagliflozin is effective in the treatment of type 2 diabetes in subjects with poor blood sugar control and moderate renal impairment

NCT ID: NCT00663052 Completed - Psoriasis Clinical Trials

Study Evaluating Etanercept for the Treatment of Moderate to Severe Psoriasis

PRISTINE
Start date: June 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the safety and efficacy of different doses of etanercept for the treatment of moderate to severe psoriasis.

NCT ID: NCT00660907 Completed - Type 2 Diabetes Clinical Trials

Efficacy and Safety of Dapagliflozin in Combination With Metformin in Type 2 Diabetes Patients

Start date: March 2008
Phase: Phase 3
Study type: Interventional

This study is being carried out to see if dapagliflozin as an addition to metformin is effective and safe in treating patients with type 2 diabetes when compared to glipizide (sulphonylurea) as an addition to metformin treatment.

NCT ID: NCT00660179 Completed - Clinical trials for Pulmonary Arterial Hypertension

Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension

SERAPHIN
Start date: May 2008
Phase: Phase 3
Study type: Interventional

The AC-055-302/SERAPHIN study will be an event-driven Phase III study, comparing two different doses of macitentan (ACT-064992) (3 and 10 mg) vs placebo in patients with symptomatic PAH. The main study objective is to demonstrate that macitentan (ACT-064992) prolongs time to the first morbidity or mortality event, and to evaluate the benefit/risk profile of macitentan (ACT-064992) in the treatment of patients with symptomatic PAH.

NCT ID: NCT00658021 Completed - Type 2 Diabetes Clinical Trials

Safety and Efficacy of Exenatide as Monotherapy and Adjunctive Therapy to Oral Antidiabetic Agents in Adolescents With Type 2 Diabetes

Start date: May 30, 2008
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to test the hypothesis that glycemic control, as measured by change in hemoglobin A1c (HbA1c) from baseline to endpoint, with exenatide is superior to that of placebo after 28 weeks of treatment in adolescent patients with type 2 diabetes who are naïve to antidiabetes agents, or patients who are being treated with metformin, an SU, or a combination of metformin and an SU