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NCT ID: NCT02569398 Terminated - Clinical trials for Asymptomatic Amyloid-positive

An Efficacy and Safety Study of Atabecestat in Participants Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia

EARLY
Start date: October 29, 2015
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate whether treatment with atabecestat slows cognitive decline compared with placebo treatment, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive Composite (PACC), in amyloid-positive participants who are asymptomatic at risk for developing Alzheimer's dementia.

NCT ID: NCT02563587 Recruiting - Pain Clinical Trials

Efficacy of Spontaneous Laughter in the Postoperative Treatment of Children

Start date: September 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the efficacy of laughter therapy in children to improve postoperative, evaluating the intensity of postoperative pain, anxiety and hospital stay.

NCT ID: NCT02563067 Completed - Asthma Clinical Trials

Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.

Start date: December 3, 2015
Phase: Phase 3
Study type: Interventional

This study aimed to determine the efficacy and safety of QAW039 and QAW039 450 mg compared to placebo, when added to GINA (Global Initiative for Asthma) steps 4 and 5 standard-of- care (SoC) asthma therapy (GINA 2016) in the following two populations: - patient with inadequately controlled severe asthma and high eosinophil counts (eosinophil count at Visit 1 ≥250 cells/ µl) (sub-population) - patients with inadequately controlled severe asthma (overall study population) Inadequate control is defined as partly controlled or uncontrolled asthma (GINA 2016)

NCT ID: NCT02563054 Completed - Gastric Cancer Clinical Trials

A Study of Capecitabine (Xeloda) in Participants With Advanced or Metastatic Gastric Cancer

Start date: April 2003
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of oral capecitabine (Xeloda) versus 5-fluorouracil (5-FU), in combination with intravenous (IV) cisplatin, in participants with advanced and/or metastatic gastric cancer. The anticipated time on study treatment is at least 6 weeks and continued up to disease progression, and the target sample size is 300 individuals.

NCT ID: NCT02562235 Active, not recruiting - Clinical trials for Hypertension, Pulmonary

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

PATENT-CHILD
Start date: October 29, 2015
Phase: Phase 3
Study type: Interventional

This study was designed to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of riociguat at age-, sex- and body-weight-adjusted doses of 0.5 mg, 1.0 mg, 1.5 mg, 2.0 mg and 2.5 mg TID in children from ≥6 to less than 18 years with pulmonary arterial hypertension (PAH) group 1. The study design consisted of a main study part followed by an optional long-term extension part. The main treatment period consisted of two phases: titration phase up to 8 weeks and a maintenance phase up to 16 weeks.

NCT ID: NCT02559583 Completed - Multiple Myeloma Clinical Trials

Observational Study in Participants With Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) in Latin America

HOLA
Start date: July 2014
Phase: Phase 4
Study type: Observational

The primary purpose of the study is to quantify participants' demographic parameters, country standard therapies, treatment patterns and outcomes among participants with chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and non-Hodgkin's lymphoma (NHL) in oncology concentration hospitals in Latin America.

NCT ID: NCT02558296 Completed - Clinical trials for Type 2 Diabetes Mellitus

Bexagliflozin Efficacy and Safety Trial

BEST
Start date: October 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the effect of bexagliflozin in lowering hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM) and increased risk of cardiovascular adverse events. The data from this study will be combined with the data from other bexagliflozin studies in a meta-analysis of CV safety outcomes.

NCT ID: NCT02557100 Completed - Clinical trials for Rheumatoid Arthritis

Study to Assess Changes in the Immune Profile in Adults With Early Rheumatoid Arthritis

Start date: November 19, 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study is to examine changes in immune cells and proteins in response to treatment with two approved therapies for Rheumatoid arthritis (RA), abatacept versus adalimumab, both given in combination with methotrexate.

NCT ID: NCT02555800 Recruiting - Clinical trials for Recurrent Respiratory Papillomatosis

Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis

Start date: December 2014
Phase: Phase 2
Study type: Interventional

The aim of this study is to compare the efficacy of intralesional bevacizumab, a monoclonal antibody against vascular endothelial growth factor, versus the antiviral drug cidofovir in patients with recurrent respiratory papillomatosis.

NCT ID: NCT02554786 Completed - Asthma Clinical Trials

A Multicenter Randomized 52 Week Treatment Double-blind, Triple Dummy Parallel Group Study to Assess the Efficacy and Safety of QMF149 Compared to Mometasone Furoate in Participants With Asthma

Start date: December 29, 2015
Phase: Phase 3
Study type: Interventional

The purpose of the trial is to evaluate the efficacy and safety of two different doses of QMF149 (QMF149 150/160 µg and QMF149 150/320 µg via Concept1) over two respective MF doses (MF 400 µg and MF 800 µg via Twisthaler® (total daily dose)) in poorly controlled asthmatic participants as determined by pulmonary function testing, and effects on asthma control