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NCT ID: NCT00160524 Completed - Crohn's Disease Clinical Trials

A follow-on Safety Study of CDP870 in Subjects With Crohn's Disease (CD) Who Have Completed a 26-week Double Blind Study CDP870-031 [NCT00152490] or CDP870-032 [NCT00152425]

PRECiSE 3
Start date: July 2004
Phase: Phase 3
Study type: Interventional

An open-label follow-on safety study of CDP870 (400 mg every 4 weeks) in patients with Crohn's Disease who have completed a 26-week blinded study (CDP870-031 [NCT00152490] or CDP870-032 [NCT00152425]).

NCT ID: NCT00160212 Completed - Hypertension Clinical Trials

Study to Evaluate the Efficacy and Safety of SLV306 in Subjects With Hypertension

Start date: December 2004
Phase: Phase 2
Study type: Interventional

This study is to compare the efficacy and safety of increasing doses of SLV306 with amlodipine.

NCT ID: NCT00158899 Completed - Dyslipidaemia Clinical Trials

GW501516 In Subjects Who Have Low Level Of High-Density Lipoprotein Cholesterol

Start date: August 2004
Phase: Phase 2
Study type: Interventional

The purpose of this clinical research study is to compare up to 3 doses of an investigational drug GW501516 to placebo (an inactive pill that looks like GW501516) to see if it is safe, well tolerated and effective in improving (raising) low levels of "good cholesterol", high-density lipoprotein cholesterol (HDLc), as compared to placebo.

NCT ID: NCT00144339 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients

Start date: December 2002
Phase: Phase 3
Study type: Interventional

The primary objective of this trial is to determine whether daily treatment with tiotropium (Spiriva®, Bromuro de Tiotropio®) inhalation capsule via HandiHaler® reduces the rate of decline in lung function over time in patients with COPD.

NCT ID: NCT00143143 Completed - Epilepsies, Partial Clinical Trials

Pregabalin Open-Label Extension Trial in Patients With Partial Seizures

Start date: September 2001
Phase: Phase 3
Study type: Interventional

The primary purpose of the protocol is to evaluate the long-term safety of pregabalin in patients with partial seizures.

NCT ID: NCT00141323 Completed - Osteoporosis Clinical Trials

Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL)

PEARL
Start date: November 2001
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine the safety and effectiveness of 2 doses of the investigational drug, lasofoxifene, compared to placebo (an inactive substance) in reducing new spinal fractures in women with osteoporosis.

NCT ID: NCT00141102 Completed - Osteoarthritis Clinical Trials

Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis

CONDOR
Start date: October 2005
Phase: Phase 4
Study type: Interventional

To determine whether celecoxib is superior to combined therapy with diclofenac and omeprazole in the incidence of clinically significant upper and/or lower gastrointestinal (GI) events in high GI risk subjects with osteoarthritis and/or rheumatoid arthritis.

NCT ID: NCT00133952 Completed - Clinical trials for Diabetic Macular Edema

Effect of Ruboxistaurin on Clinically Significant Macular Edema

Start date: August 2005
Phase: Phase 3
Study type: Interventional

The purpose of the study is to test the hypothesis that oral administration of ruboxistaurin will reduce the occurrence of sustained moderate visual loss (SMVL) in patients with clinically significant macular edema. SMVL is defined as a 15 letter or more decrease from baseline in best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity that is sustained for the patient's last 6 months of study participation. The SMVL data from this study will be combined with the SMVL data from Study B7A-MC-MBDL for the purpose of comparing ruboxistaurin to placebo.

NCT ID: NCT00125346 Terminated - Cystic Fibrosis Clinical Trials

Tobramycin Inhalation Powder (TIP) in Cystic Fibrosis Subjects

EVOLVE
Start date: September 2005
Phase: Phase 3
Study type: Interventional

Lung infections are a chronic problem for patients with cystic fibrosis (CF). Some patients with CF may have a type of bacteria called Pseudomonas aeruginosa in their lungs that can cause infections or make their symptoms worse. Tobramycin inhalation solution (TOBI) is an approved antibiotic, which is inhaled directly into the lungs, and can be used to manage these infections. Tobramycin inhalation powder (TIP) is a new, experimental powder formulation of tobramycin that is inhaled directly into the lungs using a T-326 inhaler. The purpose of this research study is to determine if TIP is safe and effective when compared to placebo (a powder with no medicine) treatment.

NCT ID: NCT00111670 Completed - Clinical trials for Diabetes Mellitus Type 2

A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes

Start date: June 2005
Phase: Phase 2
Study type: Interventional

This study will assess the efficacy, safety and tolerability of DPP-IV Inhibitor compared to placebo in patients with type 2 diabetes. The anticipated time on study treatment is < 3 months and the target sample size is 100-500 individuals.