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NCT ID: NCT05494242 Completed - Ophthalmopathy Clinical Trials

Single Superior ILM/ERM Flap for the FTMH.

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

In this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.

NCT ID: NCT05494229 Terminated - Ophthalmopathy Clinical Trials

Autologous Blood for Full-thickness Macular Hole

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

Autologous blood for primary and recurrent holes

NCT ID: NCT05486026 Completed - Clinical trials for Osteo Arthritis Knee

Efficacy of Duloxetine Compared to NSIADs in Osteoarthritis of Knee

Duloxetine
Start date: August 20, 2022
Phase: Phase 2
Study type: Interventional

Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 25% of the population . Knee OA is an insidious disease related to structural changes in the joint over many years. Progressive articular damage results in a loss of the extracellular matrix of cartilage in addition to changes in subchondral bone. Duloxetine, a selective serotonin, and norepinephrine reuptake inhibitor, it seems to be effective in treating neuropathic and chronic pain conditions.

NCT ID: NCT05449808 Recruiting - Pulmonary Embolism Clinical Trials

Evaluation of Thromboprophylaxis Appropriateness in Hospitalized Medical Patients

Start date: November 13, 2022
Phase:
Study type: Observational

Considering observational studies that suggested a relationship between acutely ill medical patients and venous thromboembolism (VTE), interventional studies with anticoagulant medications indicated a marked decline in VTE during and after hospitalization. Despite the therapeutic value of lowering this result, there is a low inclination to utilize anticoagulants in patients hospitalized for acute medical diseases. This observational research aims to assess the appropriateness of venous thromboprophylaxis offered to patients admitted to internal medicine wards.

NCT ID: NCT05430971 Recruiting - Clinical trials for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry

Start date: July 1, 2022
Phase:
Study type: Observational [Patient Registry]

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a very rare hematologic malignancy. Despite recent advances, at present there is no consensus on the optimal treatment of BPDCN. The optimal therapy of disease remains to be determined, and due to the rarity of cases, there is a need for international collaboration to collect data on BPDCN clinical presentations, diagnostics, treatment regimens and outcomes. Therefore, the objectives of this study are: (1) to build a large database of patients with BPDCN, (2) to investigate the characteristics and outcome of the disease with different treatment regimens, (3) to evaluate prognostic factors, and (4) to generate data-based prospective treatment recommendations.

NCT ID: NCT05427643 Active, not recruiting - Clinical trials for Dental Implantation, Endosseous

Evaluation of the Effect of Injectable Platelet Rich Fibrin on Stability of Dental Implant for Narrow Ridges

Start date: December 15, 2021
Phase: N/A
Study type: Interventional

the main aim of the study is to evaluate the secondary implant stability when using dental implants with injectable platelet rich fibrin accompanied by non-autogenous bone graft material in narrow ridge cases versus straightforward ridges , in clinical comparative study.

NCT ID: NCT05419687 Recruiting - Workplace Violence Clinical Trials

Violence Against Health Care Workers in Fragile Settings

VIA-H
Start date: November 1, 2022
Phase: N/A
Study type: Interventional

The general objective of the project is to assess whether a violence de-escalating training for health professionals and of a publicly displayed Code of Conduct (a set of rules developed through a citizen science and co-design approach) for both health professionals and clients at the level of the health facility, can reduce the incidence and severity of episodes of violence, and to identify the most cost-effective way to implement these interventions in rural Democratic Republic of Congo (DRC) and in the mega city of Baghdad, Iraq.

NCT ID: NCT05403164 Recruiting - Periodontitis Clinical Trials

Epithelial Mesenchymal Transition and Periodontitis

Start date: July 12, 2021
Phase:
Study type: Observational

Periodontitis is a chronic inflammatory disease results is destruction of the attachment apparatus of the teeth and ultimately tooth loss. Epithelial-mesenchymal transition (EMT) is a process comprises of series of events that influence a polarized epithelial cell to undergo molecular/morphological changes leading to acquisition of mesenchymal cell phenotype. This process is responsible for suppressing epithelial-phenotype and it is known to be triggered by chronic exposure to inflammatory cytokines, Gram-negative bacteria, hypoxia, smoking, and hyperglycemia. Both periodontitis and EMT share common risk factors/promoters; however, the role of EMT in the pathogenesis of periodontitis is not fully elucidated yet. Potential induction of EMT within periodontal pockets may disrupt epithelial barrier thus facilitating invasion of pathogenic periodontal pathogens to deeper tissues resulting in further tissue breakdown and non-resolving periodontal lesion.

NCT ID: NCT05398874 Completed - Knee Osteoarthritis Clinical Trials

Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.

NCT ID: NCT05391542 Completed - Aligning Archwires Clinical Trials

Effectiveness of Tubular Coaxial Nickel-titanium and Copper Nickel-titanium Orthodontic Aligning Archwires

Start date: February 28, 2022
Phase: N/A
Study type: Interventional

This study will be done to compare the effectiveness of using coaxial tubular superelastic nickel-titanium and copper-nickel-titanium archwires during the initial phase of orthodontic treatment regarding alignment efficiency, pain perception, and root resorption.