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NCT ID: NCT00388726 Completed - Breast Cancer Clinical Trials

E7389 Versus Treatment of Physician's Choice in Patients With Locally Recurrent or Metastatic Breast Cancer

Start date: November 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare Overall Survival (OS), Progression Free Survival (PFS), objective tumor response rate, duration of response, and safety in patients treated with E7389 versus the Treatment of Physician's Choice (TPC) in patients with locally recurrent or metastatic breast cancer.

NCT ID: NCT00388505 Completed - Cystic Fibrosis Clinical Trials

Safety of Tobramycin Inhalation Powder (TIP) vs Tobramycin Solution for Inhalation in Patients With Cystic Fibrosis

EAGER
Start date: February 2006
Phase: Phase 3
Study type: Interventional

This study compares the safety of the tobramycin solution for inhalation with the tobramycin dry powder formulation, used with a simple inhaler

NCT ID: NCT00387309 Completed - Clinical trials for Post Operative Bowel Dysfunction

Study Evaluating IV Methylnaltrexone for the Treatment of Post Operative Ileus

Start date: December 2006
Phase: Phase 3
Study type: Interventional

Primary Objective: In subjects who have undergone segmental colectomy, the time between the end of surgery and first bowel movement is significantly shorter with the investigational MOA-728 regimen than with a placebo regimen.

NCT ID: NCT00387127 Completed - Clinical trials for Neoplasms, Head and Neck

Lapatinib Versus Placebo Given Concurrently With Cisplatin And Radiotherapy In Patients With Unresected Head And Neck Cancer

Start date: November 2006
Phase: Phase 2
Study type: Interventional

This is a phase II study comparing the effects of lapatinib versus placebo when administered concurrently with cisplatin and radiotherapy followed by 1 year monotherapy with lapatinib or placebo. The study is designed to evaluate and compare the two treatment groups with respect to complete response rate at 6 months following chemoradiation completion.

NCT ID: NCT00387088 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Tiotropium / Respimat One Year Study in COPD.

Start date: September 2006
Phase: Phase 3
Study type: Interventional

The objective of the study is to evaluate the long-term (one year) efficacy and safety of tiotropium delivered by the Respimat inhaler in patients with COPD. Specifically, the study will examine the effect of treatment on COPD exacerbations.

NCT ID: NCT00385736 Completed - Ulcerative Colitis Clinical Trials

Efficacy and Safety of Adalimumab in Subjects With Moderately to Severely Acute Ulcerative Colitis

Start date: November 2006
Phase: Phase 3
Study type: Interventional

The objective of this study is to assess the efficacy and safety of adalimumab for the induction of clinical remission in subjects with moderately to severely active ulcerative colitis.

NCT ID: NCT00384358 Completed - Fractures Clinical Trials

Feasibility And Safety Study Of rhBMP-2/CPM For Hip Fractures

Start date: December 2006
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to assess the safety of administering rhBMP-2/CPM as an adjuvant to internal fixation in subjects with fractures of the proximal femur.

NCT ID: NCT00384189 Completed - Asthma Clinical Trials

A Comparative Study of Inhaled Ciclesonide Versus Placebo in Children With Asthma (6-11 y) (BY9010/M1-209)

Start date: October 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the efficacy of inhaled ciclesonide at three different dose levels compared with placebo with respect to pulmonary function, asthma symptoms, and use of rescue medication in children with asthma. Treatment medication will be administered as follows: ciclesonide or placebo will be inhaled once daily. The study consists of a baseline period (2 to 4 weeks) and a treatment period (12 weeks). The study provides further data on safety and tolerability of ciclesonide.

NCT ID: NCT00384176 Completed - Colorectal Cancer Clinical Trials

First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX

HORIZON III
Start date: August 30, 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab) in combination with FOLFOX.

NCT ID: NCT00382720 Completed - Stomach Neoplasms Clinical Trials

Docetaxel and Oxaliplatin in Gastric Cancer

Start date: September 2006
Phase: Phase 2
Study type: Interventional

This phase II study addressed the use of docetaxel in combination with oxaliplatin with or without 5-FU or capecitabine in metastatic or locally recurrent gastric cancer previously untreated with chemotherapy for advanced disease. Prior to this study a pilot phase I (part I) determined the optimal dose by assessing the safety and tolerability of 2 dose levels in each arm. The optimal dose was administered in the Part II study. Participants who received the optimal dose in each treatment arm in Part I were included in the Part II analysis population. Primary objective: - To assess the time to progression (TTP) of Docetaxel in combination with Oxaliplatin with or without 5-Fluorouracil (5-FU) or Capecitabine in metastatic or locally recurrent gastric cancer previously untreated with chemotherapy for advanced disease (part II). Secondary objectives: - To establish the safety profile. - To assess the Overall Response Rate (ORR) based on the World Health Organization (WHO) criteria - To assess the Overall Survival (OS)