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NCT ID: NCT00650767 Completed - Clinical trials for Rheumatoid Arthritis

A Study of ARRY-438162 in Patients With Rheumatoid Arthritis

Start date: March 2008
Phase: Phase 2
Study type: Interventional

This is a Phase 2 study, involving a 12-week treatment period, designed to evaluate the effectiveness of investigational study drug ARRY-438162 in treating rheumatoid arthritis in patients on stable doses of methotrexate, and to further evaluate the safety of the study drug. Approximately 200 patients from the US, Argentina, Brazil, Hungary, Peru, Poland and Romania will be enrolled in this study.

NCT ID: NCT00650078 Completed - Clinical trials for Rheumatoid Arthritis

Study to Assess the Safety and Efficacy of Modified-Release Prednisone (Lodotra®) Therapy in Patients With Active Rheumatoid Arthritis

CAPRA-2
Start date: March 2008
Phase: Phase 3
Study type: Interventional

The purpose of the study is to compare the safety and efficacy, with regards to the signs and symptoms, of MR prednisone (Lodotra®) versus placebo in combination with standard Disease Modifying Anti-Rheumatic Drug (DMARD) treatment in patients with active rheumatoid arthritis.

NCT ID: NCT00649025 Completed - Asthma Clinical Trials

A Study Comparing the Safety and Efficacy of Fluticasone and Formoterol Combination (FlutiFormâ„¢) With Fluticasone or Flovent to Treat Moderate to Severe Asthma in Adolescents and Adults

Start date: March 2008
Phase: Phase 3
Study type: Interventional

The medications being used in this study are individually approved by the Food and Drug Administration (FDA). The medication under investigation is a combination of two medications in one inhaler. The purpose of this study is to determine how well your asthma is controlled when taking one of the three treatment.

NCT ID: NCT00648453 Completed - Clinical trials for Peripheral Arterial Disease

Effect of Plavix on NO (Nitrogen Monoxide) Production of the Endothelial Function

Start date: December 2002
Phase: Phase 4
Study type: Interventional

To determine whether in the laser Doppler flowmetric parameters characteristic of endothelial dysfunction at patients with clinically manifest atherosclerosis any change can be detected at plavix (clopidogrel) treatment. Laser Doppler /LD/ measurement combined with iontophoresis evaluates the effect of acetylcholine /ACh/ /endothelium dependent/ and sodium nitroprusside /NSP/ /endothelium independent/ on the microcirculation of the skin

NCT ID: NCT00645684 Completed - Clinical trials for Gastrointestinal Diseases

Clinical Use of an Absorbable Coated Suture Material in Surgery (Safil)

Start date: April 1998
Phase: Phase 4
Study type: Interventional

The purpose is to test a coated polyglycolic acid multifilament suture in gastrointestinal surgery as part of a controlled randomized single blinded parallel group trial. The applicability and safety of the strand material used in two suture techniques (2-layer suture technique vs. 1-layer running) are to be tested on the basis of handling characteristics, the operative time consumed for the construction of the 1st anastomosis, the average time of the hospital duration for both patient groups, and the frequency of postoperative complications after discharge, 1 month and a maximum of 3-4 months. The used suture units are counted and the length of sutures determined which will be an indirect measurement of the costs of suture material for the two techniques.

NCT ID: NCT00645411 Completed - Influenza Clinical Trials

Pediatric Safety and Immunogenicity Study of Cell-Culture Derived and Egg-based Subunit Influenza Vaccines in Healthy Children and Adolescents

Start date: October 2007
Phase: Phase 2/Phase 3
Study type: Interventional

The present study is the first study designed to evaluate safety, tolerability and immunogenicity of the cell culture-derived influenza vaccine in healthy children and adolescents aged 3 to 17 years. A step-down approach is utilized in which reactogenicity and safety will be assessed in children and adolescents 9 to 17 years of age (Cohort 1) prior to enrolling additional children and adolescents 9 to 17 years of age (Cohort 2) and children 3 to 8 years of age (Cohort 3).

NCT ID: NCT00644605 Completed - Clinical trials for Hypertension, Pulmonary

A Study to Assess the Efficacy and Safety of 20, 40, and 80mg of Sildenafil Three Times a Day in the Treatment of Pulmonary Arterial Hypertension

Start date: October 2002
Phase: Phase 3
Study type: Interventional

To evaluate the effect of three doses of oral sildenafil (20, 40 and 80 mg three times a day [TID]) on exercise capacity, as measured by the 6-Minute Walk test, as well as the safety and tolerability, after 12 weeks of treatment in subjects with pulmonary arterial hypertension who are aged 18 years and over. To investigate the plasma concentration-effect relationship and to determine the population pharmacokinetic (PK) parameters.

NCT ID: NCT00644553 Completed - Clinical trials for Acute Bacterial Sinusitis (ABS)

Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis

Start date: May 2003
Phase: Phase 3
Study type: Interventional

To compare the safety/tolerability and efficacy of a 14-day course of clarithromycin extended-release tablets (2 x 500 mg QD) with that of a 14-day course of amoxicillin-clavulanate tablets (875/125 mg BID) for the treatment of ambulatory subjects with Acute Bacterial Sinusitis (ABS).

NCT ID: NCT00643929 Completed - Clinical trials for Purpura, Thrombocytopaenic, Idiopathic

LENS - Long-term Eltrombopag Observational Study

LENS
Start date: February 2007
Phase: N/A
Study type: Observational

A long term observational ocular safety study in adults who have received study medication (either active drug or placebo) in a phase II or III clinical study evaluating eltrombopag. The study will follow subjects for 2.5 years following their last ocular assessment on their prior treatment study (regardless of the therapeutic indication) and will describe long-term ocular safety with respect to changes in the lenses over time from all subjects.

NCT ID: NCT00643201 Completed - Venous Thrombosis Clinical Trials

Efficacy and Safety Study of Apixaban for the Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Start date: July 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effects of an investigational blood thinner, apixaban, in preventing venous thromboembolic (VTE) recurrence or death in patients with deep vein thrombosis (DVT) or pulmonary embolism (PE)