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NCT ID: NCT03254472 Completed - Clinical trials for Inappropriate Prescribing

Defining Use And Misuse of Biomarkers Dosage and Trends in Observed Concentration

rUBIDIuM
Start date: February 17, 2010
Phase: N/A
Study type: Observational

We conducted a retrospective analysis of all measured concentrations performed in a large subset of laboratories located in the French Brittany from February 2010 the 17th to August 2015 the 30th, in adults over 20 years old. We were aimed at studying physicians' use and eventually misuse of biomarkers dosage and the characteristics of a broad population based on some biomarkers concentrations.

NCT ID: NCT03254420 Recruiting - Prostate Cancer Clinical Trials

Study Evaluating Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.

RCMIGI
Start date: August 30, 2016
Phase: Phase 2
Study type: Interventional

The Calypso® System (Varian Medical Systems, Inc., Palo Alto, CA) is a recent technology using electromagnetic transponders implanted within the prostate. It is a real-time target tracking system that takes into account both inter- and intrafractional target motion. So the exact position and movement of the prostate can be determined during radiation therapy treatment. The aim of this study is to assess pelvic late toxicity rate after intensity-modulated radiotherapy (IMRT) when using the Calypso® System with a reduction of treatment margins. In this randomized study, patients will receive IGRT treatment using the Calypso system or a conventional IGRT treatment.

NCT ID: NCT03254264 Recruiting - Clinical trials for Autism Spectrum Disorder

Impact of Early Interventions on Neurocognitive Profile of Children With Autism Spectrum Disorder

IDEAEYE
Start date: May 29, 2017
Phase: N/A
Study type: Interventional

The Early start Denver model (Rogers, 2010; Dawson, 2010) is a developmental and behavioral model that aim to enhance socio-comunicative abilities and also global development of children with Autism spectrum disorder (ASD). The purpose of this study is to identify changes in neurocognitive profile of children population with ASD receiving Early Start Denver Model (ESDM) applied 12 hours per week in comparison to children receiving other interventions. That is a study proposed to children with ASD and their families that participate already to a randomized control study called IDEA registered on clinicaltrials.gov NCT02608333. We hypothesized that ESDM would increase social cognition, reduce shifting attention time and increase preference for unpredictable stimuli.

NCT ID: NCT03253939 Completed - Gastric Cancer Clinical Trials

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Carcinomatosis From Gastric Cancer

CYTO-CHIP
Start date: February 1, 2017
Phase: N/A
Study type: Observational

Gastric cancer associated peritoneal carcinomatosis has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in Gastric cancer associated peritoneal carcinomatosis. Since recurrent gastric cancer remains confined to the abdominal cavity in many patients, regional therapies like aggressive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have been investigated for Gastric cancer associated peritoneal carcinomatosis. Hyperthermic intraperitoneal chemotherapy has been used for three indications in Gastric Cancer- as an adjuvant therapy after a curative surgery, hyperthermic intraperitoneal chemotherapy has been shown to improve survival and reduce peritoneal recurrences in many randomised trials in Asian countries; as a definitive treatment in established PC, hyperthermic intraperitoneal chemotherapy along with cytoreductive surgery is the only therapeutic modality that has resulted in long-term survival in select groups of patients. While the results of randomised trials of adjuvant hyperthermic intraperitoneal chemotherapy from western centres are awaited, the role of hyperthermic intraperitoneal chemotherapy in the treatment of Gastric cancer associated peritoneal carcinomatosis is still evolving and needs larger studies before it is accepted as a standard of care.

NCT ID: NCT03253770 Completed - Cognitive Aids Clinical Trials

Use of a Hand-held Digital Cognitive Aid in Simulated Cardiac Arrest.

SIMMAX2
Start date: May 1, 2017
Phase: N/A
Study type: Interventional

Cardiac arrest is one of the most stressful situations to be managed. Our first study (MAX, accepted for publication BJA) clearly showed that it cannot be compared to other urgent and stressful situations (malignant hyperthermia, anaphylactic shock, acute toxicity of local anesthetics, severe and symptomatic hyperkaliemia) whose management was significantly improved with the help of a digital cognitive aid. The present study exclusively deals with the management of cardiac arrest (recovery ward, or in the delivery room.) with the second generation of our digital cognitive aid, and explores new insights on how to better manage cardiac arrest with a digital cognitive aid in the hand of the leader.

NCT ID: NCT03253159 Recruiting - Breast Cancer Clinical Trials

Added Conversational Hypnosis Reduced General Anesthesia Side Effects for Day Case Breast Surgery

HYPNOSEIN
Start date: September 2014
Phase: Phase 2
Study type: Interventional

Evaluate the impact of the support in reducing postoperative adverse events in particular on the pain but also on anxiety, comfort, nausea, vomiting, and fatigue.

NCT ID: NCT03253133 Recruiting - Colorectal Cancer Clinical Trials

Assessing Safety of NIPOX in Peritoneal Carcinomatosis of CRC

NIPOX
Start date: February 2016
Phase: Phase 1
Study type: Interventional

This study determine the maximal tolerate dose

NCT ID: NCT03252912 Recruiting - Breast Cancer Clinical Trials

Study in Leptomeningeal Metastases of Breast Cancer

LCS Bio Sein
Start date: January 6, 2017
Phase: N/A
Study type: Interventional

Breast cancer (BC) is the most frequent cause of leptomeningeal metastases (LM) .As for brain parenchymal metastases, the incidence of LM seems to be increasing, due to the growing incidence of metastatic BC, the improvement of survival and the poor diffusion of therapeutic agents into the central nervous system (CNS). Several prognostic factors have been identified, including the age at diagnosis, the functional and neurological status, the delay between the diagnosis of cancer and that of LM. The survival of patients is poor, less than 6 months in most published series. Several neuronal biomarkers could also be good candidates, such as the neurogranin CSF and/or serum levels or the CNS neurofilaments (NF), that seem to be a good reflect of axonal injury and neuronal loss. CNS NF have been investigated in several neurological diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis, but not yet in CNS metastases. Indeed, the creation of a clinico-biological collection seems to be of high value in order to investigate future biomarkers of interest

NCT ID: NCT03252717 Recruiting - Breast Cancer Clinical Trials

Predictive Role of New Biomarkers for Hypersensitive Patients to Radiation in Breast Cancer (BIORISE)

BIORISE
Start date: August 2014
Phase: N/A
Study type: Interventional

To confirm the protein expression level in radiation-induced late effects patients and to determine the performance value, in particular the positive predictive value, of a blood test based on the dosage of a panel of five proteins, it is necessary to validate these preliminary results by a prospective study on a large cohort of patients.

NCT ID: NCT03252587 Not yet recruiting - Clinical trials for Systemic Lupus Erythematosus

An Investigational Study to Evaluate BMS-986165 in Patients With Systemic Lupus Erythematosus

Start date: September 12, 2017
Phase: Phase 2
Study type: Interventional

This study will investigate BMS-986165 to assess its effects in patients with systemic lupus erythematosus (SLE).