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NCT ID: NCT03306225 Recruiting - Clinical trials for Endocarditis, Bacterial

Characterization of Endocarditis to Streptococci and Impact of the CMI on the Future of the Patients

Start date: July 8, 2016
Phase: N/A
Study type: Observational

The infectious endocarditis is a grave infection the incidence of which is at present esteemed at 30-100 episodes by million inhabitants a year. This infection is marked with a heavy morbi-mortality.Preliminary studies seem to show an abnormally high death rate at the patients presenting an infectious endocarditis to streptococci with an inhibitive minimal concentration raised to the amoxicilline. The aim of the study is to describe the epidemiology and the clinical presentations of the patients presenting an endocarditis to streptococci

NCT ID: NCT03305978 Recruiting - Lung Cancer Clinical Trials

Pulmonary Nodule Detection: Comparison of an Ultra Low Dose vs Standard Scan.

npUBD
Start date: September 26, 2017
Phase: N/A
Study type: Interventional

Lung cancer screening programs are still discussed in Europe today, and one of the concern is radiation due to iterative CT. The aim of this monocentric, prospective, non randomized study is to compare an ultra low dose chest CT (approaching a two views X ray) versus a standard low dose chest CT for ≥4mm lung nodules detection, and secondary for lung nodule characterization and smoking associated findings (emphysema, bronchial abnormalities and coronary calcifications).

NCT ID: NCT03305926 Not yet recruiting - Clinical trials for Coronary Artery Disease

Connected Rehabilitation: an Alternative to Conventional Cardiovascular Rehabilitation?

eRCV
Start date: December 2017
Phase: N/A
Study type: Interventional

Cardiovascular rehabilitation (CVR) has major beneficial effects by improving physical capacity, accelerating return to activities and reinsertion and reducing mortality. It associates reconditioning to effort and therapeutic education for the optimal control of " risk factors ". It corresponds to a global approach to patients, thus counterbalancing the tendency to hyperspecialise in medicine. However, because of the lack of specialised centres, only a small proportion of patients (≈30%) are able to benefit. Numerical tools used in e-health, the deployment of the Internet and certain " connected " devices may provide alternatives outside hospital, by enabling the follow-up of patients and their physiological parameters (heart rate, blood pressure, weigh, physical activity…), and the adaptation - using an interactive web platform - of the physical activity programme, nutrition, compliance with medication and weaning from smoking. This project proposes to evaluate the effects of a so-called " connected " CVR programme, and to show its non-inferiority compared with a conventional CVR.

NCT ID: NCT03305640 Completed - Acetabular Fracture Clinical Trials

Identification of an Atypical acetabuLar frActure With an Independent Roof Component: Incidence and Description

Start date: May 27, 2016
Phase: N/A
Study type: Observational

Treatment of acetabular fractures needs a perfect diagnosis to anticipate surgical difficulties. E. Letournel described a rare atypical both-column fracture which " introduces enormous surgical difficulties ". Its particularity is a sagittal comminution interesting the acetabular roof. In this experience the particular fracture is probably under-diagnosed. The purpose of this study is to give the exact incidence and a precise description of these fractures to improve their surgical management.

NCT ID: NCT03305601 Completed - Pregnancy Related Clinical Trials

Information During Maternity

Start date: July 8, 2016
Phase: N/A
Study type: Interventional

During the pregnancy , it's now compulsary for the doctors to inform pregnant women and the couple about the medical, non medical informations and explain the physiological changes . As usual, medical staff and doctors explain and inform by oral and with a booklet patient. In order to cluster and make more accessible these informations, the maternity team of GHPSJ has developed an application on smartphone . If this application has been evaluated on his contents and accordance to recommendations, there is no evaluation about the satisfaction of patient. The aim is to study the impact of this kind of application on pregnant women satisfaction.

NCT ID: NCT03305315 Not yet recruiting - Clinical trials for Diseases of the Temporomandibular Joint

Study of Temporomandibular Joint Dysfunction

CinématiqueATM
Start date: October 2017
Phase: N/A
Study type: Observational

Given the frequency of temporomandibular joint (TMJ) dysfunction and the variations in its expression, this project intends to initiate a process of objective evaluation of mandible function and its impairment due to different diseases. The first step is to determine whether 3D kinematic quantification of the mandible would make it possible to objectively assess the effect of post-operative management on TMJ function recovery. If the first results are encouraging and show the sensitivity of the analysis of minor joint dysfunctions, we will evaluate the feasibility of kinematic assessments for major TMJ dysfunctions and for the follow-up of patients. The expected benefits of this study are to be considered in the medium term and concern the possibilities offered by measuring mandible kinetics in the treatment of TMJ disorders.

NCT ID: NCT03305302 Recruiting - Clinical trials for Cancer of the Tongue

Isolation and Establishment of Gustatory Cell Lines in Patients Operated on for Cancer of the Mobile Tongue - ImmortTasteCELL

Start date: April 5, 2017
Phase: N/A
Study type: Observational

In terms of incidence, cancer of the tongue is one of the leading cancers in France. Moreover, this cancer is associated with physiological complications ranging from swallowing disorders to loss of taste. Following surgery, impaired perception of food taste may lead to cachexia. It is therefore necessary to carry out research in the field of impaired taste, notably with regard to the regeneration of taste buds. However, there is currently no available functional model of taste bud cells. It is therefore necessary to obtain a cell line of human taste cells. These immortalised human cells will allow us to better orient our investigations for applications in humans: search for and characterisation of "taste modifiers" synthesised using organic chemistry, able to trigger the perception of food in cases of taste loss or taste impairment. Moreover, given recent studies conducted by the investigating team proposing the existence of a fatty taste and its implication in obesity, the work of the team could be oriented towards the synthesis of lipid-receptor agonists, by analogy with artificial sweeteners instead of sugar. The availability of these chemical molecules would lead to a reduction in lipid intake as these agents contain no (or very few) calories. They will act as an organoleptic decoy.

NCT ID: NCT03305211 Not yet recruiting - Kidney Disease Clinical Trials

Biological Collection in Nephrology for the Study of the Links Between Kidney Disease, Immunity System and Cardiovascular Complications

NéphroMIC²
Start date: December 15, 2017
Phase: N/A
Study type: Interventional

The NephoMIC project is a biological collection in patients of Nephrology, allowing the study of the links between kidney diseases, Immunity system and Cardiovascular complications. Its aim is to allow the development of a translational research on the theme of "Systemic Nephrology", which concerns both renal complications of autoimmune and inflammatory diseases, and systemic complications of patients with kidney disease, linked to both a state of immunosuppression and an increased risk of cardiovascular complications. It is based on the proximity between the Clinical investigation Center (CIC) of the hospital, where the samples are received, techniqued and preserved, and the Center of Nephrology and Renal Transplantation of the hospital. The collection includes blood samples (whole blood, serum, plasma, total blood RNA, PBMC cells), and urine samples (fresh urine). Participation in the collection is particularly recommended for patients who require a medical renal biopsy in the Nephrology Department. Other well-phenotyped patients (well-defined renal disease diagnosis) may also participate in NephroMIC.

NCT ID: NCT03305198 Not yet recruiting - Clinical trials for Peripheral Artery Disease

BIOlogical Response to Exercise : A Metabolomic Study in Peripheral Artery Disease (BIOR)

BIOR
Start date: October 2017
Phase: N/A
Study type: Interventional

The measurement of the transcutaneous oxygen pressure during walking allows to estimate the importance of ischemia, bilaterally and segment of limb by segment of limb. The determination of the metabolic compounds concentration, with metabolomic approach, is emerging in physiology and exercise. This pilot study focuses on the feasibility of the metabolomics analysis with micro method , by capillary drawing from earlobe sampling, for patients with peripheral artery disease (PAD)

NCT ID: NCT03305146 Recruiting - Pancreatic Cyst Clinical Trials

Feasibility of Molecular Biology in Pancreatic Cyst Tumors

CYST-GEN
Start date: January 2017
Phase: N/A
Study type: Interventional

The main objective of the study is to compare the diagnostic accuracy of intra-cystic fluid DNA molecular analysis to standard diagnostics. The secondary objective of the study is to evaluate the feasibility of intra-cystic fluid DNA molecular analysis.