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NCT ID: NCT03586635 Not yet recruiting - Clinical trials for MS CHRONIC PROGRESSIVE

Automated EDSS Score Calculation by Smartphone Application

Start date: September 15, 2018
Study type: Observational

The EDSS score is the reference tool for rating disability in patients with multiple sclerosis. It is used in both daily monitoring and clinical research studies. Its main shortcoming lies in its imprecise and variable nature, with significant inter-examiner variability. This variability is the consequence of the complexity of the score rating and also of its subjective nature. The application developed aims to reduce the risk of rating error, and to homogenize the results obtained regardless of the examiner and his experience in using the score.

NCT ID: NCT03586505 Recruiting - Keratitis Clinical Trials

Tolerance to Light for Patients Suffering From Keratitis

Start date: July 3, 2018
Phase: N/A
Study type: Interventional

In order to develop an innovative device to study infectious keratitis, we need to illuminate the cornea of patients suffering from an infectious keratitis with red or near-infrared light. Because of technical reasons the shortest possible wavelength (red) presents advantages.

NCT ID: NCT03586492 Not yet recruiting - Clinical trials for Ischemic Heart Disease

Coronary Flow Reserve (CFR) in Cardiovascular Risk Stratification

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

CFR has been studied for few years using 82 Rubidium PET (positron emission tomography) /CT. CFR has shown to be correlated with cardiovascular events occurring in the 10 following years. CFR also helps to identify multivessel coronary disease. Few studies have shown the possibility to calculate CFR during myocardial perfusion SPECT on new ultrafast CZT cameras.

NCT ID: NCT03586258 Recruiting - Clinical trials for Cerebrovascular Disorders

Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2

Start date: July 2018
Phase: N/A
Study type: Interventional

Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative/developmental disorders and selective cognitive disorders; (ii) healthy control subjects. The objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional, magnetic stimulation) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.

NCT ID: NCT03585842 Recruiting - Clinical trials for Substance Related Disorders

French Validation of the Dual Diagnosis Screening Interview (F_DDSI)

Start date: March 14, 2018
Study type: Observational

In France, there are no tools for screening psychiatric comorbidities for individuals with Substance Use Disorders. The literature shows that the cooccurrence of these psychiatric disorders in the same individual is frequent. It negatively impacts the healing prognosis, complicates the diagnostic processes and the type of care to be introduced for patients. The creation of reliable, fast and easy-to-use tools for caregivers and researchers is therefore necessary to improve quantitatively and qualitatively the care of patients. There is a Spanish scale that meets these criteria, the Dual Diagnostic Screening Interview (S_DDSI). The main objective of this study is to validate the DDSI in French. The secondary objectives are the evaluation of the psychometric qualities of F_DDSI (French version) and adaptation of this scale into an application for Android and iOS.

NCT ID: NCT03585816 Recruiting - Pneumoperitoneum Clinical Trials

Composition of the Exhaust Gas of Pneumoperitoneum During Laparoscopic Surgery

Start date: January 1, 2015
Study type: Observational

This research aims to study the composition of the peritoneal exhaust gas during laparoscopic surgery to detect and possibly quantify the presence of air and / or N2O. This purely descriptive work is part of other experimental work that the investigators have already published.

NCT ID: NCT03585439 Recruiting - Clinical trials for Surgical Procedure, Unspecified

Isthmic Spondylolisthesis Treated With Combined Approach: Clinical and Radiological Outcomes

Start date: June 28, 2018
Study type: Observational

This study aims to evaluate clinical and radiological outcomes of isthmic spondylolisthesis surgically treated with combined approach. The goal is to demonstrate that it is a safe and efficient technique to treat isthmic spondylolisthesis. There is very little literature concerning this procedure.

NCT ID: NCT03585075 Completed - Laryngeal Neoplasms Clinical Trials

Characterization of the Autofluorescence of Healthy and Pathological Tissues of Vocal Cords

Start date: February 2014
Study type: Observational

The aim of this clinical trial is to provide information about autofluorescence of pathological versus healthy vocal folds tissues. Experimentations are performed on vocal folds biopsies obtained from patients, surgered at ENT department, university hospital of Besançon. After being extracted, samples of vocal folds are submitted to excitations at 365 nm, 405 nm and 450 nm; light spectral absorptions are measured, and results are compared to reference anatomopathology.

NCT ID: NCT03584711 Recruiting - Clinical trials for Metastatic Colorectal Cancer

FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment, as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation

Start date: April 26, 2018
Phase: Phase 2
Study type: Interventional

Single-arm, multi-centre phase II study The primary objective is to evaluate the time to failure of the strategy.

NCT ID: NCT03584477 Recruiting - Stroke Clinical Trials

Robotic Rehabilitation of the Upper Limb After a Stroke

Start date: October 30, 2014
Phase: N/A
Study type: Interventional

Hemiparesis is the most common motor disorder after a stroke. The majority of the affected patients do not recover the functional use of their paretic upper limb. Devices providing robotic assistance improve motor training by repetition of a large number of movements, usually oriented tasks (pointing tasks, tracking paths tasks...). These devices therefore intensify the rehabilitation, a key principle to stimulate brain plasticity. The InMotion Arm 2.0 robot works with an adaptive algorithm that provide patients with real-time Assistance-as-Neededâ„¢ to improve motor performance. Hypothesis: In the sub-acute phase of stroke, the structured practice of a large number of repetitions of movements will increase the motor function of the upper limb compared to conventional rehabilitation. Secondly, this practice will be more effective in a free active mode (without assistance) than a partially active assisted mode (Assistance-as-Neededâ„¢). Expected secondary benefits: The subjective impression of improved use of the upper limb in activities of daily living and a reduction of spastic cocontractions affecting the agonist and antagonist muscles during movements of the upper limb. Objectives: The controlled protocol will evaluate the effects of structured repetition programs of arm movements, on the function of the upper hemiparetic limb and motor control, between 4 and 10 weeks after the stroke, using a robotic device with or without assistance replacing a part of conventional rehabilitation care, compared to a program with only conventional rehabilitation care.