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Depression, Postpartum clinical trials

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NCT ID: NCT03665038 Recruiting - Clinical trials for Post Partum Depression

A Study to Assess the Safety and Efficacy of Brexanolone in the Treatment of Adolescent Female Subjects With Postpartum Depression

Start date: May 17, 2018
Phase: Phase 3
Study type: Interventional

This study is a multi-center, double-blind, placebo-controlled study evaluating the efficacy, safety, tolerability, and pharmacokinetics of Brexanolone in the treatment of adolescent female subjects with postpartum depression.

NCT ID: NCT03654261 Recruiting - Clinical trials for Postpartum Depression

1-Day CBT Workshops for PPD

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Postpartum depression (PPD) affects up to 20% of women and has profound effects on women and their families. Clinical practice guidelines recommend that the majority of women with PPD receive psychotherapy. The purpose of this pilot study is to successfully adapt and deliver a 1-day CBT workshop for depression to women with PPD, establish the feasibility of a study protocol, and generate an estimate of the treatment effect (as well as its variance) in this population for a later, large-scale study. A previously validated 1-day CBT workshop has been adapted for depression for use with women experiencing PPD and living in the community. 30 women will be randomized to active treatment (n=15) or a 12 week wait list (n=15) in each setting and compare changes in depression, mother-infant attachment, service utilization, quality of life, and offspring behaviour.

NCT ID: NCT03646539 Not yet recruiting - Depression Clinical Trials

RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood

Start date: August 30, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the efficacy of an evidence-based smartphone application (app) for the management of mood compared to treatment as usual alone among 135 women who have been discharged post-delivery from Labor and Delivery at Stanford Children's Health - Lucile Packard Children's Hospital. Using psychometrically validated surveys for depression, postpartum depression, and anxiety, this study will evaluate whether the smartphone app has a differential effect on the mental health of postpartum women as compared to treatment as usual.

NCT ID: NCT03638687 Recruiting - Bipolar Disorder Clinical Trials

Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers

Start date: May 2014
Phase:
Study type: Observational

Through a recent cross species translational experiment, researchers have identified a set of epigenetic marks capable of predicting postpartum depression with greater than 85% accuracy. The researchers are looking to identify a group of women from both the general population and those with a history of mood disorders who are at risk for postpartum depression and obtain brain imaging data at a postpartum time period prior to the onset of depressive symptoms and compare it with those obtained during depressive episodes. The researchers will also evaluate the efficacy of postpartum depression biomarker prediction.

NCT ID: NCT03615794 Recruiting - Clinical trials for Major Depressive Disorder

A Study of Pregnant and Postpartum Women With and Without Mood Disorders

Start date: October 1, 2017
Phase:
Study type: Observational

This study is looking at genetic, biological, and environmental causes and how all three may work together to cause postpartum mood episodes. Participants will have psychiatric histories taken and will be monitored throughout pregnancy and during the postpartum period for the development of depressive or other mood episodes. Biological measures, including hormone levels, immunological measures, and growth factors will be collected. Environmental factors such as sleep deprivation and stress will also be measured. These factors will be considered in the setting of genetic and epigenetic data with the hope that investigators will ultimately be able to predict the onset of postpartum mood episodes in this vulnerable population.

NCT ID: NCT03596879 Recruiting - Insomnia Clinical Trials

Insomnia and Rumination in Late Pregnancy and the Risk for Postpartum Depression

PPD
Start date: July 18, 2018
Phase: N/A
Study type: Interventional

The primary objective of the proposed research is to determine whether prenatal insomnia and ruminative thinking predict severity of postpartum depression (PPD) symptoms. Additionally, the investigators will also determine the effectiveness of digital/internet-based Cognitive Behavioral Therapy for Insomnia (dCBTI) in reducing the risk for PPD.

NCT ID: NCT03593473 Enrolling by invitation - Anxiety Disorders Clinical Trials

Inhaled Oxytocin and HPA Axis Reactivity

Start date: July 2018
Phase: Phase 2
Study type: Interventional

Mothers who were enrolled in the Mood, Mother and Infant study will be eligible to participate in the 6-year follow-up maternal visit. At the time of this visit, mothers will be randomized to a single 24 IU dose of nasal oxytocin or placebo. Following administration of the study drug, women will participate in the Trier Social Stress Test (TSST), and blood samples will be collected to quantify HPA axis reactivity.

NCT ID: NCT03574766 Not yet recruiting - Anxiety Clinical Trials

Meditation for NICU Moms

Start date: September 2018
Phase: N/A
Study type: Interventional

This project explores whether meditation increases breastmilk supply in mothers who are pumping milk for infants in the NICU. Mothers will be randomly assigned to daily meditation while pumping using an app designed for meditation for new mothers, and their breastmilk volume will be measured after one week of meditation versus a control group with measurements at the same time points. Investigators will also determine whether mediation improves breastfeeding confidence and reduces stress, anxiety and depression symptoms in these mothers. Finally investigators will examine the effect on biomarkers obtained through blood and saliva tests of stress, mood and milk production.

NCT ID: NCT03573713 Active, not recruiting - Clinical trials for Depression, Postpartum

Decreasing Stunting by Reducing Maternal Depression in Uganda: A Cluster Randomized Controlled Trial (CRCT) for Improved Nutrition Outcomes

Start date: September 11, 2017
Phase: N/A
Study type: Interventional

The project seeks to test the integration of Interpersonal Psychotherapy for Groups within Care Group projects and investigate whether the treatment of maternal depression with Interpersonal Psychotherapy for Groups improves the adoption of nutrition-related behaviors that can reduce stunting in the Kitgum District in northern Uganda. A secondary aim is to examine whether the participation in the care groups will also result in remission of depression as a non-specific therapeutic effect although it may not be intended as an antidepressant treatment.

NCT ID: NCT03499756 Not yet recruiting - Clinical trials for Postnatal Depression

Couple-based Interpersonal Psychotherapy on Postnatal Depression and Family Sense of Coherence

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

Postnatal depression is a common public health problem which has long-term sequelae on the family and the infant's psychosocial development. Interpersonal psychotherapy has demonstrated its value as one of the most effective interventions for postnatal depression. The aim of this study is to examine the effect of a couple-based interpersonal psychotherapy for first-time Chinese mothers and fathers on depressive symptoms, family sense of coherence, and marital relationships immediately after intervention and at 6 weeks and 6 months postpartum.