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NCT ID: NCT04076514 Recruiting - Clinical trials for Papillary Thyroid Cancer

The Role of Central Neck Dissection in Stage N0 Papillary Thyroid Carcinoma

pCND
Start date: September 1, 2020
Phase:
Study type: Observational

The benefits of prophylactic central neck dissection (pCND) remain controversial in clinically node-negative (cN0) papillary thyroid carcinoma (PTC). This study main goal is to investigate benefits of prophylactic central neck dissection in clinically node-negative papillary thyroid carcinoma.

NCT ID: NCT04071197 Recruiting - Clinical trials for Progressive Familial Intrahepatic Cholestasis

Gastrostomy-Biliary Diversion: Innovative Management for Bile Canalicular Transport Disorders

Start date: March 10, 2020
Phase: N/A
Study type: Interventional

Progressive familial intrahepatic cholestasis (PFIC) is a group of disorders that can present early in life with cholestasis and intractable pruritus. Their treatment poses a great challenge, with medical treatment is not successful in many cases. Moreover, the available non-transplant surgeries carry many side effects and different degrees of efficacy. Partial external biliary diversion, internal biliary diversion, and ileal exclusion still lack widespread experience with many side effects. Nasobiliary stent placement has little tolerability, especially in younger age. Gastrobiliary tube is a novel modality for external biliary diversion in such patients.

NCT ID: NCT04070859 Recruiting - Glenoid; Fracture Clinical Trials

Fixation of Glenoid Fractures

Start date: July 1, 2019
Phase:
Study type: Observational

Scapula fractures are uncommon but make up 3-5% of all shoulder girdle injuries. Moreover, intraarticular glenoid fossa fractures represent only 1% of scapula fractures. They are frequently found with concomitant injuries to chest, head, brachial plexus and humerus. The glenoid is an oval shaped portion on the lateral border of the scapula that articulates with the circular rounded end of the humeral head. Superiorly the glenoid is part of the superior shoulder suspensory complex (SSSC) consisting of superior glenoid, coracoid process, coracoclavicular ligaments, distal end of the clavicle, acromioclavicular joint, coracoacromial ligament and acromial process. Subsequently, stability of the shoulder is a complex mechanism in which muscles, ligamentous and capsular restraints, the labrum and joint vacuum, each play a role depending on position and activity. The history of patients with glenoid fractures will mostly consist of either shoulder dislocation or direct trauma to the humeral head. The affected arm is "pseudo-paralysed" and supported in adduction and internal rotation. Because of a thick layer of soft tissue, only mild swelling and ecchymosis may be seen . For the diagnosis of scapular injuries X-rays are routinely taken , MSCT scanning , MRI & Nerve conduction velocity may be done. Main parameters defining operative treatment are instability, the articular surface fragment size and the degree of displacement. However, concomitant injuries (e.g. thorax, head, extremity fractures, plexus lesion), age, occupation, level of activity and dominance, play a key role in management.

NCT ID: NCT04069780 Recruiting - Safety Clinical Trials

Suprachoroidal Injection of Triamcinolone Acetonide for Management of Diabetic Macular Edema

SCI
Start date: March 13, 2019
Phase: N/A
Study type: Interventional

Intravitreal triamcinolone acetonide is a well-known method of treatment of diabetic macular edema, however, it has many side effects, most commonly causing cataract and glaucoma. Suprachoroidal route is an emerging route of delivery of intraocular drugs. This is to our knowledge the first prospective study to compare the effect of triamcinolone acetonide delivered via the intravitreal versus the suprachoroidal route in the treatment of diabetic macular edema as regards safety and efficacy.

NCT ID: NCT04062279 Recruiting - Parkinson Disease Clinical Trials

Predictors of Parkinson's Disease Progression

PDPROG-EGY
Start date: November 15, 2019
Phase:
Study type: Observational [Patient Registry]

it is a prospective longitudinal observational study, aiming to to identify clinical, and biochemical baseline predictors of motor and non-motor PD progression in sample of Egyptian patients. it measures the baseline motor, non-motor, biochemical and imaging characteristics at enrollment and its relation to PD progression over 3 years

NCT ID: NCT04055779 Recruiting - Vascular Diseases Clinical Trials

Minimal Inflation Tourniquet Pressure Using Induced Hypotension

Start date: August 1, 2019
Phase:
Study type: Observational

Limb occlusion pressure (LOP) and arterial occlusion pressure (AOP) are the terms that mean the lowest tourniquet pressure required to stop the arterial blood flow into the limb distal to the cuff. LOP can be determined manually or automatically by slow cuff inflation until disapper of pulsation with Doppler flow-meter or pulse oximeter

NCT ID: NCT04055194 Recruiting - Placenta Previa Clinical Trials

Antenatal Tranexamic Acid in Women With Symptomatic Placenta Previa

Start date: August 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

200 pregnant women with symptomatic placenta previa with previous bleeding attacks attending Ain Shams University maternity hospital will be recruited and randomized to receive either tranexamic acid tablets (500mg four times daily) or placebo. Amount of bleeding during antepartum bleeding attacks will be estimated (by hemoglobin change from baseline at admission till delivery).

NCT ID: NCT04049838 Recruiting - Pain, Postoperative Clinical Trials

Ultrasound Guided Posterior Versus Lateral Transversus Abdominis Plan Block for Prolonged Postoperative Analgesic Effect in Children

Start date: February 16, 2019
Phase: N/A
Study type: Interventional

Ultrasound Guided Posterior Versus Lateral Transversus Abdominis Plan Block for Prolonged Postoperative Analgesic Effect in Children

NCT ID: NCT04045626 Recruiting - Clinical trials for Progressive Keratoconus

Study of Demarcation Line Depth in Transepithelial Versus Epithelium-off Accelerated Cross-linking (AXL) in Keratocouns

Start date: August 1, 2019
Phase: N/A
Study type: Interventional

To assess depth of demarcation line in transepithelial versus epithelium-off accelerated cross-linking in keratoconus patients

NCT ID: NCT04043858 Recruiting - Children, Only Clinical Trials

Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children

Start date: June 5, 2020
Phase: N/A
Study type: Interventional

Ascites in liver cirrhosis is explained by increased production of vasoactive substances leading to renal vasoconstriction and salt and water retention. The retained water then accumulates in the peritoneal cavity under the effect of portal hypertension and low albumin. Refractory ascites is defined as ascites that cannot be mobilized or prevented from early recurrence after large-volume paracentesis despite medical therapy and dietary sodium restriction. Midodrine is an α1 receptor agonist that can improve systemic and renal hemodynamics in non-azotemic cirrhotic patients by counteracting mesenteric vasodilatation, which is accentuated in cirrhosis.