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NCT ID: NCT03393286 Recruiting - Zika Virus Clinical Trials

ZIKAlliance Children Cohort (ZIKAllianceCH)

ZIKAllianceCH
Start date: January 15, 2018
Phase: N/A
Study type: Observational

The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations. We will estimate the absolute and relative risks of congenital malformations and other adverse outcomes of pregnancy among women who become infected with ZIKV during pregnancy compared to uninfected pregnant women, also leading to further validation of the Congenital Zika Syndrome.

NCT ID: NCT03371017 Recruiting - Clinical trials for Triple Negative Breast Neoplasms

A Study of the Efficacy and Safety of Atezolizumab Plus Chemotherapy for Patients With Early Relapsing Recurrent Triple-Negative Breast Cancer

IMpassion132
Start date: January 31, 2018
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of atezolizumab plus chemotherapy compared with placebo plus chemotherapy in patients with inoperable recurrent triple-negative breast cancer (TNBC).

NCT ID: NCT03296254 Active, not recruiting - Clinical trials for Mental Health Wellness 1

Comparison of Two Brief Mindfulness Intervention for Stress, Anxiety and Burnout in Mental Health Professionals

Start date: January 22, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to examine the effectiveness of two mindfulness interventions for stress, anxiety and burnout in mental health professionals. Participants will receive the treatments in reverse order: a brief intervention based on body exercises and another brief intervention based on sitting meditation. It is hypothesized that both interventions will decrease stress and anxiety levels and professional burnout, with mindfulness body exercises being at least as effective as mindfulness meditations.

NCT ID: NCT03188731 Recruiting - Pregnancy Related Clinical Trials

ZIKAlliance Pregnant Women Cohort

ZIKAlliancePW
Start date: May 24, 2017
Phase: N/A
Study type: Observational

The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations. We will estimate the absolute and relative risks of congenital malformations and other adverse outcomes of pregnancy among women who become infected with ZIKV during pregnancy compared to uninfected pregnant women, also leading to further validation of the Congenital Zika Syndrome.

NCT ID: NCT02862990 Recruiting - Breast Cancer Clinical Trials

Evaluation of the Attitude of Pre Menopausal Women With Breast Cancer Faced With the Risk of Fertility Loss Caused by Chemotherapy

Start date: May 2015
Phase: N/A
Study type: Observational

To evaluate the attitude of pre menopausal women with breast cancer faced with the risk of loss of fertility caused by chemotherapy using EORTC's Fertility Questionnaire.

NCT ID: NCT02765503 Recruiting - Clinical trials for Squamous Cell Carcinoma of the Head and Neck

Resource Sparing Curative Radiotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck: The HYPNO Trial

HYPNO
Start date: March 2014
Phase: Phase 3
Study type: Interventional

The aim of the study is to test whether a resource-sparing 4-week, 20-fraction course of accelerated hypofractionated radiotherapy is non-inferior to accelerated radiotherapy delivering 33 fractions over 5.5 weeks in the treatment of patients with Stage I-IV squamous cell carcinoma of the pharynx, larynx and oral cavity with the exception of paranasal sinus, nasopharyngeal and stage I-II glottic carcinomas.

NCT ID: NCT02271958 Completed - Endometriosis Clinical Trials

Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis

Start date: November 2010
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effectiveness and safety of 2.5, 5 and 10 mg doses of mifepristone against a placebo in women with laparoscopic diagnostic of endometriosis. The hypothesis of the study is that the 5 mg mifepristone dose is safe and effective and should be used in future studies on medical treatment of endometriosis.

NCT ID: NCT02145442 Completed - Obesity Clinical Trials

Effects of Obex in Overweight and Obese Patients

Start date: June 2014
Phase: Phase 2/Phase 3
Study type: Interventional

- Obesity is an important and growing public health worldwide - Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer - An extensive body of evidence from efficacy trials has shown that weight loss is achievable, however, a modest weight loss is achieved in a small proportion of patients - Important adverse events have been reported with the use of antiobesity drugs. - The use of natural products with potential effects inducing weight loss is an alternative strategy for treating patients with overweight and obesity. However, efficacy and safety should be evaluated in RCT. - Obex combines different molecules with potential effects inducing weight loss and control on metabolic parameters such as fasting glucose, cholesterol and triglycerides. - Therefore, the administration of Obex in overweight and obese patients with impaired fasting glucose could be an excellent strategy to induce weight loss and ameliorate the metabolic disturbances related to obesity and overweight.

NCT ID: NCT01786226 Terminated - Uterine Fibroids Clinical Trials

Mifepristone to Treat Uterine Fibroids

Start date: March 2010
Phase: Phase 2/Phase 3
Study type: Interventional

Objectives: to evaluate the efficacy, safety and quality of life by using 2.5 and mifepristone 5 mg daily doses to treat uterine fibroids over 3 months with a 9 months follow-up period. The hypothesis of the study is that the 2.5 mg dosage resulted in a lesser reduction in fibroid size but a similar improvement in quality of life when compared to the 5 mg dose.

NCT ID: NCT01460472 Active, not recruiting - NSCLC Clinical Trials

Immunotherapy With Racotumomab in Advanced Lung Cancer

Start date: September 2010
Phase: Phase 3
Study type: Interventional

This is a prospective, randomized, open label, parallel-group, multicenter phase III study to evaluate the efficacy and safety of active specific immunotherapy with racotumomab plus best supportive care versus best supportive care in patients with advanced NSCLC who have achieved an Objective Response (Partial or Complete Response) or Stable Disease with standard first-line treatment. Also immunological parameters will be evaluated. Best supportive therapy will be administered to all patients in the study according to institutional standards and includes any subsequent onco-specific therapies. 1082 patients will be included in the study, with non-small cell lung cancer in stages IIIA (non-resectable), IIIB or IV.