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NCT ID: NCT02862990 Recruiting - Breast Cancer Clinical Trials

Evaluation of the Attitude of Pre Menopausal Women With Breast Cancer Faced With the Risk of Fertility Loss Caused by Chemotherapy

Start date: May 2015
Phase: N/A
Study type: Observational

To evaluate the attitude of pre menopausal women with breast cancer faced with the risk of loss of fertility caused by chemotherapy using EORTC's Fertility Questionnaire.

NCT ID: NCT02765503 Recruiting - Clinical trials for Squamous Cell Carcinoma of the Head and Neck

Resource Sparing Curative Radiotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck: The HYPNO Trial

HYPNO
Start date: March 2014
Phase: Phase 3
Study type: Interventional

The aim of the study is to test whether a resource-sparing 4-week, 20-fraction course of accelerated hypofractionated radiotherapy is non-inferior to accelerated radiotherapy delivering 33 fractions over 5.5 weeks in the treatment of patients with Stage I-IV squamous cell carcinoma of the pharynx, larynx and oral cavity with the exception of paranasal sinus, nasopharyngeal and stage I-II glottic carcinomas.

NCT ID: NCT02537626 Recruiting - Alzheimer's Disease Clinical Trials

An Evaluation of the Effects of Low Level Laser Light Therapy on Improving the Symptoms of Alzheimer's Disease

Start date: May 8, 2017
Phase: N/A
Study type: Interventional

This study evaluates the effect of applying low level laser light therapy to individuals with mild to moderate Alzheimer's disease to see if it may improve their memory, thinking and behaviors. Half of the participants will receive the real treatment with the laser device and the other half of the participants will receive a placebo treatment (not active laser).

NCT ID: NCT02271958 Completed - Endometriosis Clinical Trials

Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis

Start date: November 2010
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effectiveness and safety of 2.5, 5 and 10 mg doses of mifepristone against a placebo in women with laparoscopic diagnostic of endometriosis. The hypothesis of the study is that the 5 mg mifepristone dose is safe and effective and should be used in future studies on medical treatment of endometriosis.

NCT ID: NCT02145442 Completed - Obesity Clinical Trials

Effects of Obex in Overweight and Obese Patients

Start date: June 2014
Phase: Phase 2/Phase 3
Study type: Interventional

- Obesity is an important and growing public health worldwide - Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer - An extensive body of evidence from efficacy trials has shown that weight loss is achievable, however, a modest weight loss is achieved in a small proportion of patients - Important adverse events have been reported with the use of antiobesity drugs. - The use of natural products with potential effects inducing weight loss is an alternative strategy for treating patients with overweight and obesity. However, efficacy and safety should be evaluated in RCT. - Obex combines different molecules with potential effects inducing weight loss and control on metabolic parameters such as fasting glucose, cholesterol and triglycerides. - Therefore, the administration of Obex in overweight and obese patients with impaired fasting glucose could be an excellent strategy to induce weight loss and ameliorate the metabolic disturbances related to obesity and overweight.

NCT ID: NCT01786226 Terminated - Uterine Fibroids Clinical Trials

Mifepristone to Treat Uterine Fibroids

Start date: March 2010
Phase: Phase 2/Phase 3
Study type: Interventional

Objectives: to evaluate the efficacy, safety and quality of life by using 2.5 and mifepristone 5 mg daily doses to treat uterine fibroids over 3 months with a 9 months follow-up period. The hypothesis of the study is that the 2.5 mg dosage resulted in a lesser reduction in fibroid size but a similar improvement in quality of life when compared to the 5 mg dose.

NCT ID: NCT01460472 Active, not recruiting - NSCLC Clinical Trials

Immunotherapy With Racotumomab in Advanced Lung Cancer

Start date: September 2010
Phase: Phase 3
Study type: Interventional

This is a prospective, randomized, open label, parallel-group, multicenter phase III study to evaluate the efficacy and safety of active specific immunotherapy with racotumomab plus best supportive care versus best supportive care in patients with advanced NSCLC who have achieved an Objective Response (Partial or Complete Response) or Stable Disease with standard first-line treatment. Also immunological parameters will be evaluated. Best supportive therapy will be administered to all patients in the study according to institutional standards and includes any subsequent onco-specific therapies. 1082 patients will be included in the study, with non-small cell lung cancer in stages IIIA (non-resectable), IIIB or IV.

NCT ID: NCT01459328 Recruiting - Rectal Carcinoma Clinical Trials

Resource-Sparing Curative Treatment for Rectal Cancer

Start date: September 2009
Phase: Phase 3
Study type: Interventional

This is a prospective, multicentre, randomized clinical trial comparing two different neo-adjuvant radiation-based strategies prior to intended surgery for locally advanced adenocarcinoma of the rectum. This trial may establish the investigational therapy to be superior to, or at least not inferior to conventional treatment.

NCT ID: NCT01452672 Recruiting - Breast Cancer Clinical Trials

Resource-sparing Post-mastectomy Radiotherapy in Breast Cancer

Start date: March 2007
Phase: Phase 3
Study type: Interventional

This study compares two different field set-ups in patients with breast cancer following a breast resection (mastectomy). These two set-ups are as follows: arm a - radiotherapy to the chest-wall only, and arm b - radiotherapy to the chest-wall and the supraclavicular fossa. Patients in both treatment arms will receive radiotherapy with a shortened fractionation schedule. Study hypothesis: irradiation of the chest-wall only is not inferior to irradiation of the chest-wall and supraclavicular fossa in terms of loco-regional control, survival and treatment toxicity.

NCT ID: NCT01285726 Completed - Clinical trials for Chronic Renal Failure

Initiative for Patient Outcomes in Dialysis - Peritoneal Dialysis (PD) (IPOD-PD Study)

IPOD-PD
Start date: January 2011
Phase: N/A
Study type: Observational

The aim of the study is to asses the hydration status of incident peritoneal dialysis (PD) patients and its evolution over a period of four years, independent of the PD treatment modality (APD or CAPD) and the PD solution type.